ArticleNature communications2023
Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.Immunological reviews · 2026Review
- Multi-omics data mining combined with experimental validation reveals ferroptosis- and autophagy-associated hub genes as diagnostic candidates and immune modulators in atherosclerosis.Animal models and experimental medicine · 2026Article
- Role and mechanisms of vascular smooth muscle cell phenotypic transition in diabetic macrovascular complications.Biological research · 2026Review
- Biomaterials Promote the Regression of Atherosclerotic Plaque by Regulating Cell Behavior.International journal of nanomedicine · 2026Review
- Inflammatory bowel disease through the lens of microbe-host interactions: immunomodulation, metabolic effects, and genetic susceptibility in microbiota dysbiosis.Frontiers in cellular and infection microbiology · 2026Review
- Regulatory roles of PIWI-interacting RNAs in cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2025Review
- VPS28 regulates triglyceride synthesis via ubiquitination in bovine mammary epithelial cells.Scientific reports · 2024Article
- Novel Metal-Free Nanozyme for Targeted Imaging and Inhibition of Atherosclerosis via Macrophage Autophagy Activation to Prevent Vulnerable Plaque Formation and Rupture.ACS applied materials & interfaces · 2024Article
- Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling.Clinical and translational medicine · 2024Article
- TREM2 protects from atherosclerosis by limiting necrotic core formation.Nature cardiovascular research · 2024Article
- Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism.Frontiers in immunology · 2024Review
- Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?Biochemical pharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 6 institutions in 5 countries.
Yujiao ZhangUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-0982-858X
Marie Vandestienne *Université Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-6947-9852
Jean-Rémi Lavillegrand *Université Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Jeremie JoffreUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Icia Santos-ZasUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Aonghus LavelleSorbonne Université, Paris, France.
Xiaodan ZhongUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Wilfried Le GoffInserm UMRS1166, ICAN, Institute of CardioMetabolism and Nutrition, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.ORCID 0000-0002-7611-9644
Maryse GuérinInserm UMRS1166, ICAN, Institute of CardioMetabolism and Nutrition, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.
Rida Al-RifaiUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-6976-0011
Ludivine LauransUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Patrick BrunevalUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Coralie GuérinInstitut Curie, Cytometry Platform, 75006, Paris, France.ORCID 0000-0002-1840-4017
Marc DiedisheimClinique Saint Gatien Alliance (NCT+), 37540 Saint-Cyr-sur-Loire, France; Institut Necker-Enfants Malades (INEM), Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, 75015, Paris, France.ORCID 0000-0002-0418-1107
Melanie MigaudLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Imagine Institute, 75015, Paris, France.ORCID 0000-0003-3062-1214
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Imagine Institute, 75015, Paris, France.
Fanny LanternierLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Imagine Institute, 75015, Paris, France.
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Imagine Institute, 75015, Paris, France.
Clément CochainComprehensive Heart Failure Center Wuerzburg, University Hospital Wuerzburg, Wuerzburg, Germany.
Alma ZerneckeInstitute of Experimental Biomedicine, University Hospital Wuerzburg, Wuerzburg, Germany.
Antoine-Emmanuel SalibaHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Wuerzburg, Germany.ORCID 0000-0001-8539-2784
Michal MokryLaboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands.ORCID 0000-0002-5298-4852
Jean-Sebastien SilvestreUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0003-3962-2205
Alain TedguiUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-7229-4875
Ziad MallatUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.
Soraya TalebUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-6650-619X
Olivia LenoirUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0001-8107-6987
Cécile VindisCIC 1436/CARDIOMET, Inserm, 1048, Toulouse, France.
Stéphane M CamusUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France.ORCID 0000-0002-4326-1724
Harry SokolSorbonne Université, Paris, France.ORCID 0000-0002-2914-1822
Hafid Ait-OufellaUniversité Paris Cité, INSERM U970, Paris Cardiovascular Research Center, Paris, France. hafid.aitoufella@inserm.fr.ORCID 0000-0002-2955-0183
Inserm · FRUniversitätsklinikum Würzburg · DECentre National de la Recherche Scientifique · FRHelmholtz Institute for RNA-based Infection Research · DEInstitut Curie · FRUtrecht University · NL
Funding
Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova · 2017 to 2026
$4.8MBritish Heart Foundation CH/10/001/27642NIAID NIH HHS R01 AI127564
Abstract
Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe
Indexed as
AtherosclerosisAnimalsApolipoproteins EAutophagyCandidiasis, Chronic MucocutaneousCARD Signaling Adaptor ProteinsHumansLipidsMiceMice, Inbred C57BLMice, KnockoutApolipoproteins ECARD9 protein, humanCard9 protein, mouseCARD Signaling Adaptor ProteinsLipids
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.