Evidence map›Paper›PMID 37528309›Full record

ArticleCurrent topics in behavioral neurosciences2023

The Impacts of Sex Differences and Sex Hormones on Fear Extinction.

Eric Raul Velasco, Antonio Florido, Laura Perez-Caballero, Ignacio Marin, Raul Andero

Abstract read
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In one paragraph

Article in Current topics in behavioral neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric Raul VelascoInstitut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Antonio FloridoInstitut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Laura Perez-CaballeroInstitut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ignacio MarinInstitut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Raul AnderoInstitut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain. raul.andero@uab.cat.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fear extinction memories are strongly modulated by sex and hormonal status, but the exact mechanisms are still being discovered. In humans, there are some basal and task-related features in which male and female individuals differ in fear conditioning paradigms. However, analyses considering the effects of sex hormones demonstrate a role for estradiol in fear extinction memory consolidation. Translational studies are taking advantage of the convergent findings between species to understand the brain structures implicated. Nevertheless, the human brain is complex and the transfer of these findings into the clinics remains a challenge. The promising advances in the field together with the standardization of fear extinction methodologies in humans will benefit the design of new personalized therapies.

Indexed as

Extinction, PsychologicalFearEstradiolFemaleGonadal Steroid HormonesHumansMaleSex CharacteristicsEstradiolGonadal Steroid HormonesEstradiolFear extinctionProgesteroneSex differencesSex hormones

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.