Evidence map›Paper›PMID 37528732›Full record

ArticleOpen biology2023

Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis.

Nina Rößler, Tassilo Jungenitz, Albrecht Sigler, Alexander Bird, Martin Mittag, Jeong Seop Rhee, Thomas Deller, Hermann Cuntz, Nils Brose, Stephan W Schwarzacher and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Population Morphology Implies a Common Developmental Blueprint forbioRxiv : the preprint server for biology · 2025
    Article
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  5. Article
  6. Article
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  8. Article
  9. Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nina RößlerFaculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.ORCID 0009-0001-1181-1007
Tassilo JungenitzNeuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.ORCID 0000-0001-7291-8548
Albrecht SiglerDepartment of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.
Alexander BirdFaculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.ORCID 0000-0003-4895-8253
Martin MittagFaculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.ORCID 0000-0002-6429-2423
Jeong Seop RheeDepartment of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.
Thomas DellerNeuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.
Hermann CuntzFaculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.ORCID 0000-0001-5445-0507
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Multidisciplinary Sciences, Göttingen, 37077, Germany.
Stephan W SchwarzacherNeuroscience Center, Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, 60528, Germany.
Peter JedlickaFaculty of Medicine, ICAR3R-Interdisciplinary Centre for 3Rs in Animal Research, Justus Liebig University Giessen, Rudolf-Buchheim-Straße 6, Giessen, D-35392, Germany.ORCID 0000-0001-6571-5742
Goethe University Frankfurt · DEMax Planck Institute for Multidisciplinary SciencesJustus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity

Indexed as

Neuronal PlasticityNeuronsAnimalsDendritic SpinesMiceNeurogenesisPyramidal CellsRatsSynapsesSynaptic Transmissionheterosynaptic plasticityintrinsic/extrinsic synaptic dynamicslognormal distributionmultiplicative noiseMunc13 double-knockout micespike-timing-dependent plasticity (STDP)

Identifiers

PMID37528732
PMCPMC10394416
OpenAlexW4385476565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.