Evidence map›Paper›PMID 37529293›Full record

ArticleQRB discovery2022

Abnormal methylation in the

Johanna Hörberg, Björn Hallbäck, Kevin Moreau, Anna Reymer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in QRB discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Johanna HörbergDepartment of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden.ORCID https://orcid.org/0000-0002-5232-3528
Björn HallbäckDepartment of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden.ORCID https://orcid.org/0000-0001-7893-2834
Kevin MoreauDepartment of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden.ORCID https://orcid.org/0000-0002-3686-0737
Anna ReymerDepartment of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden.ORCID https://orcid.org/0000-0001-8458-7918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective DNA binding by transcription factors (TFs) is crucial for the correct regulation of DNA transcription. In healthy cells, promoters of active genes are hypomethylated. A single CpG methylation within a TF response element (RE) may change the binding preferences of the protein, thus causing the dysregulation of transcription programs. Here, we investigate a molecular mechanism driving the downregulation of the

Indexed as

abnormal DNA methylationbioinformatic analysescooperative DNA bindingmolecular dynamics simulationsTranscription factor-DNA recognitiontranscription regulation

Identifiers

PMID37529293
PMCPMC10392677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.