ArticleFrontiers in endocrinology2023
Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015-2021 in a fertility center from China.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Altered Embryonic SIRT6 and SIRT7 Expression Is Associated with Impaired Developmental Competence and Oocyte-Dependent Embryo Quality in Embryos Derived from Subfertile Males.International journal of molecular sciences · 2026Article
- Oxidative Stress and Male Reproductive Health-First Edition.Antioxidants (Basel, Switzerland) · 2026Article
- The impact of junk food on male fertility in mice: therapeutic interventions targeting advanced glycation end-products and oxidative stress.Scientific reports · 2026Article
- Temporal trends in semen parameters among men attending a fertility center in the UAE (2012 - 2022): a retrospective study.Frontiers in physiology · 2026Article
- Exposure to ambient particulate matter and semen quality: the modifying role of socioeconomic status and lifestyle factors in chinese men.BMC public health · 2025Article
- Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants.Frontiers in endocrinology · 2025Article
- Morphological Parameters of 29994 sperm in a fertile male population-based on Papanicolaou staining and SSA-II Plus.Frontiers in endocrinology · 2025Article
- Sperm YOLOv8E-TrackEVD: A Novel Approach for Sperm Detection and Tracking.Sensors (Basel, Switzerland) · 2024Article
- Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective Additive.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.Frontiers in reproductive health · 2024Review
- No Evidence of Temporal Decline in Semen Parameters Over 17 Years Among Men Who Underwent Fertility Evaluation from Indian Southern States.American journal of men's healthArticle
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Authors and funding
8 authors.
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Abstract
Background: Sperm quality, including semen volume, sperm count, concentration, and total and progressive motility (collectively, "semen parameters"), has declined in the recent decades. Computer-assisted sperm analysis (CASA) provides sperm kinematic parameters, and the temporal trends of which remain unclear. Our objective is to examine the temporal trend of both semen parameters and kinematic parameters in Shanghai, China, in the recent years. Methods: This retrospective study analyzed semen parameters and kinematic parameters of 49,819 men attending our reproductive center by using CASA during 2015-2021. The total sample was divided into two groups: samples that surpassed the WHO guideline (2010) low reference limits ("above reference limit" group, ARL; n = 24,575) and samples that did not ("below reference limit" group, BRL; n = 24,614). One-way analysis of variance, Kruskal-Wallis test, independent samples Results: Among all the total sample and the ARL and BRL groups, the age of subjects increased in recent years. Semen volume and sperm count showed declined tendency with years in the total sample, the ARL and BRL groups, and the subgroup of age or abstinence time, whereas sperm velocities showed increased tendency with years on the contrary. The multiple linear regression model of the ARL group, adjusting for age and abstinence time, confirmed these trends. Semen volume (β1= -0.162; CI: -0.172, -0.152), sperm count (β1= -9.97; CI: -10.813, -9.128), sperm concentration (β1 = -0.535; CI: -0.772, -0.299), motility (β1 = -1.751; CI: -1.830, -1.672), and progressive motility (β1 = -1.12; CI: -0.201, -0.145) decreased with year, whereas curvilinear line velocity (VCL) (β1 = 3.058; CI: 2.912, 3.203), straight line velocity (VSL) (β1 = 2.075; CI: 1.990, 2.161), and average path velocity (VAP) (β1 = 2.305; CI: 2.224, 2.386) increased over time (all Conclusion: The semen parameters declined, whereas the kinematic parameters increased over the recent years. We propose that, although sperm count and motility declined over time, sperm motion velocity increased, suggesting a possible compensatory mechanism of male fertility.
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