Evidence map›Paper›PMID 37532091›Full record

ArticleDevelopmental biology2023

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.

Shiona Biswas, C Savio Chan, John L R Rubenstein, Lin Gan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Shiona BiswasThe Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14627, USA; Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14627, USA. Electronic address: shiona@gmail.com.
C Savio ChanDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
John L R RubensteinDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California at San Francisco, CA, 94143, USA.
Lin GanDepartment of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14627, USA; Department of Ophthalmology and the Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14627, USA.
University of Rochester · USNorthwestern University · USUniversity of California, San Francisco · US

Funding

Genetic Control of Basal Telencephalic DevelopmentR01MH081880 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 2009 to 2023
$8.1M
Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
The Roles of LIM-Homeodomain Transcription Factors in Retinal DevelopmentR01EY026614 · NEI · UNIVERSITY OF ROCHESTER · PI GAN, LIN · 2016 to 2020
$1.9M
Investigation of Pallidal Neurons in Motor InhibitionR56NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2022 to 2022
$536k
NEI NIH HHS R01 EY026614NIMH NIH HHS R01 MH081880NINDS NIH HHS R01 NS069777NINDS NIH HHS R56 NS069777
6 · The paper itself

Abstract

The external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both passive and active body movements. Aberrant activity of GPe neurons has been linked to motor symptoms of a variety of movement disorders, such as Parkinson's Disease, Huntington's disease and dystonia. Recent studies have helped delineate functionally distinct subtypes of GABAergic GPe projection neurons. However, not much is known about specific molecular mechanisms underlying the development of GPe neuronal subtypes. We show that the transcriptional regulator Lmo3 is required for the development of medial ganglionic eminence derived Nkx2.1

Indexed as

GABAergic NeuronsGlobus PallidusLIM Domain ProteinsMovementAnimalsMiceMice, KnockoutMovement DisordersLIM Domain ProteinsBasal gangliaGPeLmo3Medial ganglionic eminenceParvalbumin

Identifiers

PMID37532091
PMCPMC10658356
OpenAlexW4385407856

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.