Evidence map›Paper›PMID 37532594›Full record

ArticleAtherosclerosis2024

Changes in carotid arterial wall viscosity and carotid arterial stiffness in type 2 diabetes patients.

Frédéric Roca, Louise Zmuda, Gabrielle Noël, Thomas Duflot, Michèle Iacob, Lucile Moreau-Grangé, Gaëtan Prévost, Robinson Joannides, Jeremy Bellien

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02584439 (Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02584439 phase3completednot on this map

Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC)

TypeinterventionalSponsorUniversity Hospital, RouenRan2015 to 2019Enrolled20ConditionsHealthy, Vascular Stiffness, AgingArmsivabradine, lactose capsule (placebo)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Frédéric RocaNormandy University, UniRouen, Inserm UMR1096 EnVI, FHU REMOD-VHF, F-76000, Rouen, France; Department of Pharmacology, Rouen University Hospital, F-76000, Rouen, France; Department of Geriatric Medicine, Rouen University Hospital, F 76000, Rouen, France. Electronic address: Frederic.roca@chu-rouen.fr.
Louise ZmudaDepartment of Pharmacology, Rouen University Hospital, F-76000, Rouen, France; Department of Geriatric Medicine, Rouen University Hospital, F 76000, Rouen, France.
Gabrielle NoëlDepartment of Pharmacology, Rouen University Hospital, F-76000, Rouen, France; Department of Geriatric Medicine, Rouen University Hospital, F 76000, Rouen, France.
Thomas DuflotNormandy University, UniRouen, Inserm UMR1096 EnVI, FHU REMOD-VHF, F-76000, Rouen, France; Department of Pharmacology, Rouen University Hospital, F-76000, Rouen, France.
Michèle IacobDepartment of Pharmacology, Rouen University Hospital, F-76000, Rouen, France.
Lucile Moreau-GrangéDepartment of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, F 76000, Rouen, France.
Gaëtan PrévostDepartment of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, F 76000, Rouen, France; CIC-CRB U1404, CHU Rouen, F-76000, Rouen, France.
Robinson JoannidesNormandy University, UniRouen, Inserm UMR1096 EnVI, FHU REMOD-VHF, F-76000, Rouen, France; Department of Pharmacology, Rouen University Hospital, F-76000, Rouen, France; CIC-CRB U1404, CHU Rouen, F-76000, Rouen, France.
Jeremy BellienNormandy University, UniRouen, Inserm UMR1096 EnVI, FHU REMOD-VHF, F-76000, Rouen, France; Department of Pharmacology, Rouen University Hospital, F-76000, Rouen, France; CIC-CRB U1404, CHU Rouen, F-76000, Rouen, France.

Funding

TRANSPORT, TRANSFORMATION &REMEDIATION OF VOCS IN THE VADOSE ZONE &GROUND WATERP42ES004699 · UNIVERSITY OF CALIFORNIA DAVIS · 1987 to 2005
$14.0M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · UNIVERSITY OF CALIFORNIA DAVIS · 1985 to 1997
–
NIDDK NIH HHS R01 DK103616NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710
6 · The paper itself

Abstract

BACKGROUND AND

aimsChanges in arterial wall viscosity (AWW) and stiffness during type 2 diabetes (T2D) have been little investigated. We explored changes in carotid AWV considering change in arterial stiffness and loading conditions, in patients with T2D.

methodsThis cross-sectional, monocentric study compared 19 middle-aged patients with T2D to 30 non-diabetic (ND) controls. The absolute viscosity (W

resultsT2D patients were older and more frequently had hypertension. Internal diameter, mean central and pulse blood pressure were higher in T2D patients but midwall stress was similar compared to ND controls. W

conclusionsCarotid AWV and stiffness are increased in T2D patients but only AWV is significantly increased after considering loading conditions. Whether this increase in energy dissipation within the arterial wall contributes to alter cardiovascular coupling in T2D remains to be established.

Indexed as

Carotid ArteriesDiabetes Mellitus, Type 2Vascular StiffnessAgedBlood PressureCarotid Artery DiseasesCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleManometryMiddle AgedViscosityArterial stiffnessArterial wall viscosityType 2 diabetesWall stress

Identifiers

PMID37532594
PMCPMC12320932

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.