Evidence map›Paper›PMID 37532797›Full record

ArticleMolecular psychiatry2023

Imaging the brain's immune response to alcohol with [

Nakul R Raval, Gustavo Angarita, David Matuskey, Rachel Miller, Lindsey R Drake, Michael Kapinos, Nabeel Nabulsi, Yiyun Huang, Richard E Carson, Stephanie S O'Malley and 2 more

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. MAO-B status in alcohol use disorder: a [Molecular psychiatry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nakul R RavalDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0001-5637-7219
Gustavo AngaritaYale PET Center, Yale University, New Haven, CT, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0001-7508-6572
Rachel MillerDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Lindsey R DrakeDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Michael KapinosDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0001-8129-0051
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0002-9338-7966
Stephanie S O'MalleyDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Kelly P CosgroveDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0003-1351-9576
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA. ansel.hillmer@yale.edu.ORCID 0000-0002-8105-1381
Yale Cancer Center · USYale University · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Sherry Ann McKee · 2020 to 2026
$13.0M
Imaging Microglial Activation in PTSD with PETR01MH110674 · NIMH · YALE UNIVERSITY · PI COSGROVE, KELLY P., PIETRZAK, ROBERT H · 2017 to 2020
$3.1M
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIAAA NIH HHS U54 AA027989NIMH NIH HHS R01 MH110674
6 · The paper itself

Abstract

In humans, the negative effects of alcohol are linked to immune dysfunction in both the periphery and the brain. Yet acute effects of alcohol on the neuroimmune system and its relationships with peripheral immune function are not fully understood. To address this gap, immune response to an alcohol challenge was measured with positron emission tomography (PET) using the radiotracer [

Indexed as

BrainPositron-Emission TomographyBlood Alcohol ContentCytokinesFemaleHumansImmunityMaleRadionuclide ImagingReceptors, GABABlood Alcohol ContentCytokinesReceptors, GABATSPO protein, human

Identifiers

PMID37532797
PMCPMC10743097
OpenAlexW4385494908

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.