Evidence map›Paper›PMID 37533133›Full record

ArticleFluids and barriers of the CNS2023

Influence of head-over-body and body-over-head posture on craniospinal, vascular, and abdominal pressures in an acute ovine in-vivo model.

Anthony Podgoršak, Nina Eva Trimmel, Fabian Flürenbrock, Markus Florian Oertel, Margarete Arras, Miriam Weisskopf, Marianne Schmid Daners

Open access · goldAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Fluids and barriers of the CNS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anthony PodgoršakDepartment of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Nina Eva TrimmelCenter for Surgical Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Fabian FlürenbrockDepartment of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Markus Florian OertelDepartment of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Margarete ArrasCenter for Surgical Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Miriam WeisskopfCenter for Surgical Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Marianne Schmid DanersDepartment of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland. marischm@ethz.ch.
ETH Zurich · CHUniversity Hospital of Zurich · CHUniversity of Zurich · CH

Funding

Innosuisse - Schweizerische Agentur für Innovationsförderung 42749_1 IP-LSSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 315230_184913
6 · The paper itself

Abstract

introductionOptimal shunt-based hydrocephalus treatments are heavily influenced by dynamic pressure behaviors between proximal and distal ends of shunt catheters. Posture-dependent craniospinal, arterial, venous, and abdominal dynamics thereby play an essential role.

methodsAn in-vivo ovine trial (n = 6) was conducted to evaluate communication between craniospinal, arterial, venous, and abdominal dynamics. Tilt-testing was performed between -13° and + 13° at 10-min intervals starting and ending at 0° prone position. Mean pressure, pulse pressure, and Pearson correlation (r) to the respective angle were calculated. Correlations are defined as strong: |r|≥ 0.7, mild: 0.3 <|r|< 0.7, and weak: |r|≤ 0.3. Transfer functions (TFs) between the arterial and adjacent compartments were derived.

resultsStrong correlations were observed between posture and: mean carotid/femoral arterial (r = - 0.97, r = - 0.87), intracranial, intrathecal (r = - 0.98, r = 0.94), jugular (r = - 0.95), abdominal cranial, dorsal, caudal, and intravesical pressure (r = - 0.83, r = 0.84, r = - 0.73, r = 0.99) while mildly positive correlation exists between tilt and central venous pressure (r = 0.65). Only dorsal abdominal pulse pressure yielded a significant correlation to tilt (r = 0.21). TFs followed general lowpass behaviors with resonant peaks at 4.2 ± 0.4 and 11.5 ± 1.5 Hz followed by a mean roll-off of - 15.9 ± 6.0 dB/decade.

conclusionsTilt-tests with multi-compartmental recordings help elucidate craniospinal, arterial, venous, and abdominal dynamics, which is essential to optimize shunt-based therapy. Results motivate hydrostatic influences on mean pressure, with all pressures correlating to posture, with little influence on pulse pressure. TF results quantify the craniospinal, arterial, venous, and abdominal compartments as compliant systems and help pave the road for better quantitative models of the interaction between the craniospinal and adjacent spaces.

Indexed as

PostureAnimalsBlood PressureCentral Venous PressureSheepArterial blood pressureCerebrospinal fluidHydrocephalusIntracranial pressureSheep modelTilt testingTransfer function

Identifiers

PMID37533133
PMCPMC10394828
OpenAlexW4385494183

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.