Evidence map›Paper›PMID 37533689›Full record

ArticleAdvances and applications in bioinformatics and chemistry : AABC2023

Ultrasonic-Assisted Synthesis of Heterocyclic Curcumin Analogs as Antidiabetic, Antibacterial, and Antioxidant Agents Combined with in vitro and in silico Studies.

Demis Zelelew, Milkyas Endale, Yadessa Melaku, Teshome Geremew, Rajalakshmanan Eswaramoorthy, Lemma Teshome Tufa, Youngeun Choi, Jaebeom Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances and applications in bioinformatics and chemistry : AABC, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Chemical constituents in the rhizome of Curcuma longa and the pharmacological importance of curcumin hybrids.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Demis ZelelewDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.ORCID 0000-0003-3183-9346
Milkyas EndaleDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.ORCID 0000-0002-5301-9923
Yadessa MelakuDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
Teshome GeremewDepartment of Applied Biology, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.ORCID 0000-0002-3858-7105
Rajalakshmanan EswaramoorthyDepartment of Biomaterials, Saveetha Dental College and Hospital, Saveetha University, Chennai, 600 077, India.ORCID 0000-0002-8331-2100
Lemma Teshome TufaDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
Youngeun ChoiDepartment of Chemistry, Department of Chemistry Engineering and Applied Chemistry, Chungnam National University, Daejeon, 34134, Republic of Korea.ORCID 0000-0002-4442-4898
Jaebeom LeeDepartment of Chemistry, Department of Chemistry Engineering and Applied Chemistry, Chungnam National University, Daejeon, 34134, Republic of Korea.
Adama Science and Technology University · ETChungnam National University · KRSaveetha University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heterocyclic analogs of curcumin have a wide range of therapeutic potential and the ability to control the activity of a variety of metabolic enzymes. Methods: Results and Discussion: In this work, nine heterocyclic analogs derived from curcumin precursors under ultrasonic irradiation were synthesized in excellent yields (81.4-93.7%) with improved reaction time. Results of antibacterial activities revealed that compounds 8, and 11 displayed mean inhibition zone of 13.00±0.57, and 19.66±00 mm, respectively, compared to amoxicillin (12.87±1.41 mm) at 500 μg/mL against Conclusion: According to our findings, both biological activities and in silico computational studies results demonstrated that compounds 8, 11, and 16 are promising

Indexed as

ADMET predictionantibacterialantioxidantheterocyclic curcumin analogsmolecular dockingultrasonic-irradiationα-amylase

Identifiers

PMID37533689
PMCPMC10392906
OpenAlexW4385344329

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.