Evidence map›Paper›PMID 37535618›Full record

Trial reportPloS one2023

The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.

Ai Wei, Shijin Ma, Yuzhe Dou, Xiaojun Wang, Jianxiong Wu, Shuzhi Zhou, Yanfang Deng, Xinquan Liu, Dongming Li, Mengchang Yang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05429086 (Explore the Advantages of Remimazolam Used on Gastroscopy), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05429086 phase4unknown statusnot on this map

Explore the Advantages of Remimazolam Used on Gastroscopy : A Large Sample, Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Study

TypeinterventionalSponsorSichuan Provincial People's HospitalRan2022 to 2022Enrolled287ConditionsInduction of AnesthesiaArmsRemimazolam combined propofol, Remimazolam, Propofol
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  19. Clinical Pharmacokinetics, Pharmacodynamics, and Drug Interactions of Remimazolam.European journal of drug metabolism and pharmacokinetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ai WeiDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shijin MaDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yuzhe DouDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaojun WangDepartment of Anesthesiology, Yibin First People's Hospital, Yibin, China.
Jianxiong WuDepartment of Anesthesiology, Chinese Traditional Medicine Hospital of Leshan, Leshan, China.
Shuzhi ZhouDepartment of Anesthesiology, Ya'an People's Hospital, Ya'an, China.
Yanfang DengDepartment of Anesthesiology, the first People's Hospital of Liangshan Yi Autonomous Prefecture, Liangshan, China.
Xinquan LiuDepartment of Anesthesiology, Ziyang People's Hospital, Ziyang, China.
Dongming LiDepartment of Anesthesiology, Bazhong Central Hospital, Bazhong, China.
Mengchang YangDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-6813-4174
University of Electronic Science and Technology of China · CNHanzhong Central Hospital · CNSecond People’s Hospital of Yibin · CNShanghai Liangyou (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypotension is the most common adverse event under propofol-mediated sedation and is possible to cause varying degrees of damage to patients. Whereas remimazolam has a poorer sedative effect than propofol.

aimThe aim of this study was to explore the advantages of the combination of remimazolam tosylate and propofol.

methods304 patients were divided into the remimazolam tosylate group (RT group), the propofol group (P group), and the remimazolam tosylate plus propofol group(R+T group). The primary outcome was the incidence of hypotension. Secondary outcomes included the results of sedation and recovery. The safety results mainly include the incidence of Hypotension, adverse respiratory events, postoperative nausea and vomiting, hiccup, cough, body movement and bradycardia.

resultsThe incidence of hypotension was 56.7% in the P group, 12.6% in the RT group, and 31.3% in the R+P group, three groups of pairwise comparisons showed statistical differences, with P< 0.001. The incidence of body movement was significantly higher in the RT group (26.1%) than in the P group (10.3%) and the R+P group (12.5%), P = 0.004. The endoscopist satisfaction was higher in the P (3.87±0.44) and R+P (3.95±0.22)groups than in the RT(3.53±0.84) group. The incidence of adverse events, in descending order, was P group, RT group, and R+P group (93.8%vs.61.3%vs.42.7%).

conclusionCo-administration had fewer adverse events than propofol monotherapy, also had a better sedative effect and higher endoscopist satisfaction than remimazolam monotherapy.

trial registrationClinical trial registration number: NCT05429086.

Indexed as

HypotensionPropofolBenzenesulfonatesBenzodiazepinesEndoscopy, GastrointestinalHumansHypnotics and Sedatives4-methylbenzenesulfonic acidBenzenesulfonatesBenzodiazepinesHypnotics and SedativesPropofolremimazolam

Identifiers

PMID37535618
PMCPMC10399878
OpenAlexW4385516506

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.