Evidence map›Paper›PMID 37535709›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

Repeated seizures lead to progressive ventilatory dysfunction in SS

Anna D Manis, Denise R Cook-Snyder, Erin Duffy, Wasif A Osmani, Melissa Eilbes, Matthew Dillard, Oleg Palygin, Alexander Staruschenko, Matthew R Hodges

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Sleep-disordered breathing in children with neurodisabilities.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Deletion ofiScience · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anna D ManisDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-4865-5984
Denise R Cook-SnyderDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Erin DuffyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Wasif A OsmaniDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Melissa EilbesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Matthew DillardDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-3680-5527
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-5190-8356
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-1692-9055
Medical College of Wisconsin · USMedical University of South Carolina · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Role of basolateral K channels in renal salt handling and BP controlR01DK126720 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PALYGIN, OLEG · 2021 to 2024
$1.5M
Interplay between Kir4.1/Kir5.1 channels, RAAS and electrolyte balanceF31DK122647 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI MANIS, ANNA D · 2019 to 2021
$122k
Transport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–
BLRD VA I01 BX004024NHLBI NIH HHS R01 HL122358NHLBI NIH HHS R35 HL135749NIDDK NIH HHS F31 DK122647NIDDK NIH HHS R01 DK126720NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

Patients with uncontrolled epilepsy experience repeated seizures putting them at increased risk for sudden unexpected death in epilepsy (SUDEP). Data from human patients have led to the hypothesis that SUDEP results from severe cardiorespiratory suppression after a seizure, which may involve pathological deficiencies in the brainstem serotonin (5-HT) system. Rats with a genomic

Indexed as

Potassium Channels, Inwardly RectifyingSerotoninSudden Unexpected Death in EpilepsyAnimalsDeath, SuddenElectroencephalographyHumansMaleRatsSeizuresKcnj16 protein, ratPotassium Channels, Inwardly RectifyingSerotoninbreathing variabilityrespiratory depressionseizuresserotoninSUDEP

Identifiers

PMID37535709
PMCPMC10642517
OpenAlexW4385516285

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.