ArticleScience (New York, N.Y.)2023
Peptide YY: A Paneth cell antimicrobial peptide that maintains
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 87 citations in OpenAlex.
- Antifungal therapy improves microbiome dynamics in inflammatory bowel disease.Nature medicine · 2026Observational
- Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization.Cell host & microbe · 2026Article
- An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.Nature communications · 2026Article
- Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease.JHEP reports : innovation in hepatology · 2026Article
- Article
- Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity.Current opinion in immunology · 2026Review
- Cold Exposure Alleviates Colitis via Parallel Integration of Colonic Mucosal Regeneration and Ileal Antimicrobial Defense.Biomedicines · 2026Article
- Uncovering evolutionarily remote and highly potent antimicrobial peptides with protein language models.Nature biomedical engineering · 2026Article
- PepGraphormer: an ESM-GAT hybrid deep learning framework for antimicrobial peptide prediction.Journal of cheminformatics · 2026Article
- The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026Review
- From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation.Frontiers in immunology · 2026Review
- Application of edible fungi in gut microbiota regulation.NPJ science of food · 2025Review
- ETV1 is a key regulator of enteroendocrine PYY production.Disease models & mechanisms · 2025Article
- Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- Dietary tannic acid promotes intestinal clearance of C. albicans by cross-linking hyphal chitosan.PLoS pathogens · 2025Article
- Pathogenic Fungal Sensing and Responses to Stressful Host Environments.Annual review of microbiology · 2025Review
- Neuropeptide Y Boosts Intestinal Mucosal Immunity of Tilapia Infected withAnimals : an open access journal from MDPI · 2025Article
- Review
- Organic Fusion of Molecular Simulation and Wet-Lab Validation: A Promising High-Throughput Strategy for Screening Bioactive Food Peptides.Foods (Basel, Switzerland) · 2025Review
Corrections and comments
- Commented on by
Authors and funding
18 authors at 5 institutions in 2 countries.
Joseph F PierreDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-4248-1290
Brian M PetersDepartment of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-0445-2077
Diana La TorreDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Ashley M SidebottomDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-8670-9090
Yun TaoDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4835-9576
Xiaorong ZhuDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Candace M ChamDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7135-949X
Ling WangDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9146-9047
Amal KambalDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Katharine G HarrisDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6141-1207
Julian F SilvaDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-1481-9303
Olga ZaborinaDepartment of Surgery, University of Chicago, Chicago, IL, USA.
John C AlverdyDepartment of Surgery, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-1854-4551
Herbert HerzogGarvan Institute of Medical Research, Sydney, Australia.
Jessica WitchleyDepartment of Microbiology and Immunology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9859-3411
Suzanne M NobleDepartment of Microbiology and Immunology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9855-8448
Vanessa A LeoneDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4012-4377
Eugene B ChangDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-5972-8248
University of Chicago · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USGarvan Institute of Medical Research · AUUniversity of Tennessee Health Science Center · US
Funding
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI PEKOW, JOEL · 1990 to 2025
$29.8MResearch Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3MHost and microbial basis of human ulcerative colitis and pouchitis: Identification, role, mechanisms, and resource development of host susceptibility and pathobiont factorsRC2DK122394 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2019 to 2023
$10.2MPSEUDOMONAS'EFFECTS ON THE GUT BARRIER FROM SURGERYR01GM062344 · NIGMS · UNIVERSITY OF CHICAGO · PI ALVERDY, JOHN C · 2001 to 2025
$9.2MExploring the role, regulation, and antimicrobial function of Paneth cell peptides PYY and NPY in maintaining gut microbial commensalism and innate immune defenseR01DK113788 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Joseph F PIERRE · 2017 to 2026
$4.6MRole of microbial-modulated bile acid receptor signaling in breast cancerR01CA253329 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Katherine Loree Cook, Liza Makowski-Hayes · 2020 to 2026
$3.0MCandidalysin: a key mediator of Candida vaginitis immunopathologyR01AI134796 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Brian M Peters · 2018 to 2026
$2.9MProbing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1MDiurnal Oscillations in Gut Microbes and Host Immunity in Health and ObesityK01DK111785 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LEONE, VANESSA ANNE · 2017 to 2021
$723kNovel role and function of Paneth cell PYY in anti-fungal innate immunityF32DK105728 · NIDDK · UNIVERSITY OF CHICAGO · PI PIERRE, JOSEPH F · 2015 to 2015
$54kNCI NIH HHS R01 CA253329NIAID NIH HHS R01 AI134796NIDDK NIH HHS F32 DK105728NIDDK NIH HHS K01 DK111785NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK113788NIDDK NIH HHS R01 DK138072NIDDK NIH HHS RC2 DK122394NIDDK NIH HHS T32 DK007074NIGMS NIH HHS R01 GM062344
Abstract
The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY
Indexed as
Antifungal AgentsAntimicrobial PeptidesCandidaPaneth CellsPeptide FragmentsPeptide YYAnimalsHumansMiceSymbiosisAntifungal AgentsAntimicrobial PeptidesPeptide FragmentsPeptide YYpeptide YY (1-36)
Identifiers
What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.