SynthesisAdvances in nutrition (Bethesda, Md.)2023
Endogenous Ghrelin Levels and Perception of Hunger: A Systematic Review and Meta-Analysis.
Synthesis in Advances in nutrition (Bethesda, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Acute Effects of Oral Microbial Protease Co-ingestion with Whey Protein on Postprandial Plasma Amino Acid Concentrations, Appetite, and Satiety in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial.The Journal of nutrition · 2025Trial
- Article
- Human risk taking and metabolic state: No credible evidence for desacyl-ghrelin modulation of neural or behavioural effects.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Obesity: Prevalence, causes, consequences, management, preventive strategies and future research directions.Metabolism open · 2025Review
- Puberty, but not precocious puberty is influenced by weight gain in the first years of life.Endocrine · 2025Article
- Evidence of a relationship between circulating ghrelin and sleep quality in male alcohol-dependent patients after abstinence.BMC psychiatry · 2025Article
- Recovery of appetite after using a direct weight-bearing exoskeleton for walking: a case report.Spinal cord series and cases · 2025Article
- Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants.Frontiers in pediatrics · 2024Review
- Detection of natural autoimmunity to ghrelin in diabetes mellitus.Frontiers in medical technology · 2024Article
- Connection between nutrition and oncology in dogs and cats: perspectives, evidence, and implications-a comprehensive review.Frontiers in veterinary science · 2024Review
- Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGhrelin is an orexigenic hormone primarily released by the stomach and has 2 isoforms: acylated ghrelin (AG) and de-acylated ghrelin (DAG), that appear to have different functions in humans.
objectivesTo perform a systematic review and meta-analysis of the association between plasma concentrations of total ghrelin (TG), AG, and DAG and perceptions of hunger in healthy adults.
methodsThe following criteria were used for inclusion: 1) sample contained adults ≥18 y of age, 2) body mass index [BMI kg/m
resultsThe analysis included 47 studies (110 trials, n = 1799, age: 31.4 ± 12.0 y, BMI: 26.0 ± 4.75 kg/m
conclusionsGhrelin is associated with perceptions of hunger in humans, and this relationship is strengthened when AG is isolated; thus, AG may have a large impact on hunger signals in various populations. Future research should attempt to understand the role of DAG in hunger sensations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.