Evidence map›Paper›PMID 37536581›Full record

ReviewNeuroscience and biobehavioral reviews2023

Attachment across the lifespan: Examining the intersection of pair bonding neurobiology and healthy aging.

Kristen M Berendzen, Karen L Bales, Devanand S Manoli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristen M BerendzenDepartment of Psychiatry and Behavioral Sciences, USA; Center for Integrative Neuroscience, USA; Weill Institute for Neurosciences, USA; Kavli Institute for Fundamental Neuroscience, USA.
Karen L BalesDepartment of Psychology, USA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA.
Devanand S ManoliDepartment of Psychiatry and Behavioral Sciences, USA; Center for Integrative Neuroscience, USA; Weill Institute for Neurosciences, USA; Kavli Institute for Fundamental Neuroscience, USA; Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 95158, USA.

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Understanding the neural basis of social attachmentR01MH123513 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANOLI, DEVANAND SADANAND · 2020 to 2024
$3.3M
Molecular and Neural Networks Underlying Social AttachmentR01MH108319 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALES, KAREN L., SHAH, NIRAO MAHESH · 2016 to 2020
$3.1M
Research Network on Animal Models to Understand Social Dimensions of AgingR24AG065172 · NIA · UNIVERSITY OF MINNESOTA · PI Susan C. Alberts, Alessandro Bartolomucci · 2020 to 2026
$2.6M
Neural mechanisms of social attachment disruption in frontotemporal dementiaK08AG070377 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kristen Berendzen · 2023 to 2026
$676k
NIA NIH HHS K08 AG070377NIA NIH HHS P30 AG062422NIA NIH HHS R24 AG065172NIMH NIH HHS R01 MH108319NIMH NIH HHS R01 MH123513
6 · The paper itself

Abstract

Increasing evidence suggests that intact social bonds are protective against age-related morbidity, while bond disruption and social isolation increase the risk for multiple age-related diseases. Social attachments, the enduring, selective bonds formed between individuals, are thus essential to human health. Socially monogamous species like the prairie vole (M. ochrogaster) form long-term pair bonds, allowing us to investigate the mechanisms underlying attachment and the poorly understood connection between social bonds and health. In this review, we explore several potential areas of focus emerging from data in humans and other species associating attachment and healthy aging, and evidence from prairie voles that may clarify this link. We examine gaps in our understanding of social cognition and pair bond behavior. Finally, we discuss physiologic pathways related to pair bonding that promote resilience to the processes of aging and age-related disease. Advances in the development of molecular genetic tools in monogamous species will allow us to bridge the mechanistic gaps presented and identify conserved research and therapeutic targets relevant to human health and aging.

Indexed as

Healthy AgingPair BondAnimalsArvicolinaeDNA-Binding ProteinsHumansLongevityNeurobiologySocial BehaviorDNA-Binding ProteinsAgingPair bondingPrairie volesSocial attachment

Identifiers

PMID37536581
PMCPMC11073483

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.