Evidence map›Paper›PMID 37536960›Full record

ArticleBMJ open2023

Serological survey to estimate SARS-CoV-2 infection and antibody seroprevalence at a large public university: A cross-sectional study.

Ching-Wen Hou, Stacy Williams, Kylee Taylor, Veronica Boyle, Bradley Bobbett, Joseph Kouvetakis, Keana Nguyen, Aaron McDonald, Valerie Harris, Benjamin Nussle and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Ching-Wen HouVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID 0009-0009-1298-7627
Stacy WilliamsVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Kylee TaylorVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Veronica BoyleVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Bradley BobbettVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Joseph KouvetakisVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Keana NguyenVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Aaron McDonaldVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Valerie HarrisOffice of VP Research Development, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-8577-4157
Benjamin NussleVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Phillip ScharfCollege of Liberal Arts and Sciences, Arizona State University, Tempe, AZ, USA.
Megan L JehnSchool of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-6742-417X
Timothy LantOffice of VP Research Development, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-6784-2152
Mitchell MageeVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Yunro ChungVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0001-9125-9277
Joshua LaBaerVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0001-5788-9697
Vel MuruganVirginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA vel.murugan@asu.edu.ORCID 0000-0002-7368-7742
Arizona State University · USVA Office of Research and Development · USHealth Solutions (Sweden) · SELiberal Arts University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the seroprevalence of SARS-CoV-2 antibodies among adults over 18 years.

designProspective cohort study. SETTINGS: A large public university.

participantsThis study took volunteers over 5 days and recruited 1064 adult participants. PRIMARY OUTCOME MEASURES: Seroprevalence of SARS-CoV-2-specific antibodies due to previous exposure to SARS-CoV-2 and/or vaccination.

resultsThe seroprevalence of the antireceptor binding domain (RBD) antibody was 90% by a lateral flow assay and 88% by a semiquantitative chemiluminescent immunoassay. The seroprevalence for antinucleocapsid was 20%. In addition, individuals with previous natural COVID-19 infection plus vaccination had higher anti-RBD antibody levels compared with those who had vaccination only or infection only. Individuals who had a breakthrough infection had the highest anti-RBD antibody levels.

conclusionAccurate estimates of the cumulative incidence of SARS-CoV-2 infection can inform the development of university risk mitigation protocols such as encouraging booster shots, extending mask mandates or reverting to online classes. It could help us to have clear guidance to act at the first sign of the next surge as well, especially since there is a surge of COVID-19 subvariant infections.

Indexed as

COVID-19AdultAntibodies, ViralCross-Sectional StudiesHumansProspective StudiesSARS-CoV-2Seroepidemiologic StudiesUniversitiesAntibodies, ViralCOVID-19EpidemiologySARS-CoV-2

Identifiers

PMID37536960
PMCPMC10401225
OpenAlexW4385521299

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.