ArticleNature plants2023
The master growth regulator DELLA binding to histone H2A is essential for DELLA-mediated global transcription regulation.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Disruption ofPlant biotechnology (Tokyo, Japan) · 2026Article
- Physiological and transcriptomic analyses elucidate the effects of nitrogen form ratios on strawberry growth and development.BMC plant biology · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- A rootstock-centered perspective on the regulation of alternate bearing in fruit trees.Journal of experimental botany · 2026Review
- GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant.Nature chemical biology · 2025Article
- Gibberellin signalling mediates nucleocytoplasmic trafficking of Sucrose Synthase 1 to regulate the drought tolerance in rice.Plant biotechnology journal · 2025Article
- Green Revolution DELLA Proteins: Functional Analysis and Regulatory Mechanisms.Annual review of plant biology · 2025Review
- O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis.Nature communications · 2025Article
- Analysis of the Genes from Gibberellin, Jasmonate, and Auxin Signaling Under Drought Stress: A Genome-Wide Approach in Castor Bean (Plants (Basel, Switzerland) · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Depletion of Gibberellin Signaling Up-RegulatesInternational journal of molecular sciences · 2024Article
- How chromatin senses plant hormones.Current opinion in plant biology · 2024Review
- Epigenetics and plant hormone dynamics: a functional and methodological perspective.Journal of experimental botany · 2024Review
- Phosphorylation activates master growth regulator DELLA by promoting histone H2A binding at chromatin in Arabidopsis.Nature communications · 2024Article
- Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.International journal of molecular sciences · 2024Article
- A quantitative gibberellin signaling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem.Nature communications · 2024Article
- DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The DELLA genes, also known as 'Green Revolution' genes, encode conserved master growth regulators that control plant development in response to internal and environmental cues. Functioning as nuclear-localized transcription regulators, DELLAs modulate expression of target genes via direct protein-protein interaction of their carboxy-terminal GRAS domain with hundreds of transcription factors (TFs) and epigenetic regulators. However, the molecular mechanism of DELLA-mediated transcription reprogramming remains unclear. Here by characterizing new missense alleles of an Arabidopsis DELLA, repressor of ga1-3 (RGA), and co-immunoprecipitation assays, we show that RGA binds histone H2A via the PFYRE subdomain within its GRAS domain to form a TF-RGA-H2A complex at the target chromatin. Chromatin immunoprecipitation followed by sequencing analysis further shows that this activity is essential for RGA association with its target chromatin globally. Our results indicate that, although DELLAs are recruited to target promoters by binding to TFs via the LHR1 subdomain, DELLA-H2A interaction via the PFYRE subdomain is necessary to stabilize the TF-DELLA-H2A complex at the target chromatin. This study provides insights into the two distinct key modular functions in DELLA for its genome-wide transcription regulation in plants.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.