Evidence map›Paper›PMID 37538820›Full record

ArticleChemical science2023

Controllable mitochondrial aggregation and fusion by a programmable DNA binder.

Longyi Zhu, Yiting Shen, Shengyuan Deng, Ying Wan, Jun Luo, Yan Su, Mingxu You, Chunhai Fan, Kewei Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Longyi ZhuSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China kwren@njust.edu.cn.ORCID https://orcid.org/0000-0002-0898-4804
Yiting ShenSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China kwren@njust.edu.cn.
Shengyuan DengSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology Nanjing 210094 China.ORCID https://orcid.org/0000-0002-6382-0976
Ying WanIntelligent Microsystem Technology and Engineering Center, School of Mechanical Engineering, Nanjing University of Science and Technology Nanjing 210094 China wanying@njust.edu.cn.ORCID https://orcid.org/0000-0002-3409-0492
Jun LuoSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China kwren@njust.edu.cn.ORCID https://orcid.org/0000-0002-8093-5345
Yan SuIntelligent Microsystem Technology and Engineering Center, School of Mechanical Engineering, Nanjing University of Science and Technology Nanjing 210094 China wanying@njust.edu.cn.
Mingxu YouDepartment of Chemistry, University of Massachusetts Amherst MA 01003 USA.ORCID https://orcid.org/0000-0002-5279-2340
Chunhai FanSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University Shanghai 200127 China.ORCID https://orcid.org/0000-0002-7171-7338
Kewei RenSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China kwren@njust.edu.cn.ORCID https://orcid.org/0000-0001-7115-6377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA nanodevices have been feasibly applied for various chemo-biological applications, but their functions as precise regulators of intracellular organelles are still limited. Here, we report a synthetic DNA binder that can artificially induce mitochondrial aggregation and fusion in living cells. The rationally designed DNA binder consists of a long DNA chain, which is grafted with multiple mitochondria-targeting modules. Our results indicated that the DNA binder-induced

Identifiers

PMID37538820
PMCPMC10395312

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.