Evidence map›Paper›PMID 37538977›Full record

ArticleJournal of cancer metastasis and treatment2023

Two rare cancers of the exocrine pancreas: to treat or not to treat like ductal adenocarcinoma?

Nebojsa Skorupan, Shadin Ghabra, J Alberto Maldonado, Yang Zhang, Christine Alewine

Open access · diamondAbstract read
In one paragraph

Article in Journal of cancer metastasis and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nebojsa SkorupanLaboratory of Molecular Biology, NCI Center for Cancer Research, Bethesda, MD 20892, USA.
Shadin GhabraSurgical Oncology Program, NCI Center for Cancer Research, Bethesda, MD 20892, USA.
J Alberto MaldonadoLaboratory of Molecular Biology, NCI Center for Cancer Research, Bethesda, MD 20892, USA.
Yang ZhangGastrointestinal Pathology, Joint Pathology Center, Silver Spring, MD 20910, USA.
Christine AlewineLaboratory of Molecular Biology, NCI Center for Cancer Research, Bethesda, MD 20892, USA.
Center for Cancer Research · USJoint Research Center · BE

Funding

Precision Therapy to Target Pancreatic Ductal AdenocarcinomaZIABC011652 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALEWINE, CHRISTINE · 2015 to 2025
$7.9M
Rare Exocrine Tumors of the PancreasZIABC012041 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALEWINE, CHRISTINE · 2021 to 2025
$1.3M
Clinical SupportZIEBC011653 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALEWINE, CHRISTINE · 2015 to 2025
$218k
Intramural NIH HHS ZIA BC011652Intramural NIH HHS ZIA BC012041Intramural NIH HHS ZIE BC011653
6 · The paper itself

Abstract

Pancreatic cancer is an aggressive malignancy with increasing incidence. Pancreatic ductal adenocarcinoma (PDAC) accounts for > 90% of pancreatic cancer diagnoses, while other exocrine tumors are much rarer. In this review, we have focused on two rare cancers of the exocrine pancreas: adenosquamous carcinoma of the pancreas (ASCP) and pancreatic acinar cell carcinoma (PACC). The latest findings regarding their cellular and molecular pathology, clinical characteristics, prognosis, and clinical management are discussed. New genetic and transcriptomic data suggest that ASCP is related to or overlaps with the basal transcriptomic subtype of PDAC. These tumors are highly aggressive and driven by activated

Indexed as

acinar cell carcinoma of the pancreasAdenosquamous carcinoma of the pancreasrare exocrine pancreatic cancer

Identifiers

PMID37538977
PMCPMC10400043
OpenAlexW4323527382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.