Evidence map›Paper›PMID 37539732›Full record

ReviewCancer reports (Hoboken, N.J.)2023

Exploring the human microbiome - A step forward for precision medicine in breast cancer.

Asmita Jotshi, Krishna Kishore Sukla, Mohammed Monzoorul Haque, Chandrani Bose, Binuja Varma, C B Koppiker, Sneha Joshi, Rupa Mishra

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06610097 (Impacts of Diet, Activity, and Mood on a Dynamic Gut Microbiota During Treatment for Triple-negative Breast Cancer), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06610097 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Impacts of Diet, Activity, and Mood on a Dynamic Gut Microbiota During Treatment for Triple-negative Breast Cancer

TypeinterventionalSponsorScripps HealthRan2025 to 2026Enrolled0ConditionsBreast Cancer, Triple Negative Breast Cancer, Early Stage Triple-Negative Breast CarcinomaArmsNutritional Counseling
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Asmita JotshiCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM), Pune, India.
Krishna Kishore SuklaLife Sciences R&D, TCS Research, Tata Consultancy Services Limited, Pune, India.
Mohammed Monzoorul HaqueLife Sciences R&D, TCS Research, Tata Consultancy Services Limited, Pune, India.
Chandrani BoseLife Sciences R&D, TCS Research, Tata Consultancy Services Limited, Pune, India.
Binuja VarmaTCS Genomics Lab, Tata Consultancy Services Limited, New Delhi, India.
C B KoppikerCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM), Pune, India.ORCID 0000-0002-1363-274X
Sneha JoshiCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM), Pune, India.ORCID 0000-0003-3090-4767
Rupa MishraCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM), Pune, India.ORCID 0000-0002-4508-4573
Indian Institute of Science Education and Research Kolkata · INTata Consultancy Services (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe second most frequent cancer in the world and the most common malignancy in women is breast cancer. Breast cancer is a significant health concern in India with a high mortality-to-incidence ratio and presentation at a younger age. RECENT

findingsRecent studies have identified gut microbiota as a significant factor that can have an influence on the development, treatment, and prognosis of breast cancer. This review article aims to describe the influence of microbial dysbiosis on breast cancer occurrence and the possible interactions between oncobiome and specific breast cancer molecular subtypes. The review further also discusses the role of epigenetics and diet/nutrition in the regulation of the gut and breast microbiome and its association with breast cancer prevention, therapy, and recurrence. Additionally, the recent technological advances in microbiome research, including next-generation sequencing (NGS) technologies, genome sequencing, single-cell sequencing, and microbial metabolomics along with recent advances in artificial intelligence (AI) have also been reviewed. This is an attempt to present a comprehensive status of the microbiome as a key cancer biomarker.

conclusionWe believe that correlating microbiome and carcinogenesis is important as it can provide insights into the mechanisms by which microbial dysbiosis can influence cancer development and progression, leading to the potential use of the microbiome as a tool for prognostication and personalized therapy.

Indexed as

Breast NeoplasmsMicrobiotaArtificial IntelligenceDysbiosisFemaleHumansPrecision MedicineAI/MLbiomarkerbreast cancermicrobiomeoncobiomeprecision oncology

Identifiers

PMID37539732
PMCPMC10644338
OpenAlexW4385564567

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.