NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.

Elliott M Bernard, Petr Broz

Open access · bronzeAbstract readComment

In one paragraph

Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

1.4field-weighted citation impact, top 19% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

Nlrp12-driven PANoptosis exacerbates liver injury in ConA-induced autoimmune hepatitis.Genes and immunity · 2026
Article
PANoptosis links gut dysbiosis to obstructive sleep apnea-associated atherosclerosis: a gut-vascular inflammatory axis.Frontiers in immunology · 2026
Review
Targeting PANoptosis: a promising therapeutic strategy for ALI/ARDS.Apoptosis : an international journal on programmed cell death · 2025
Review
PANoptosis in neurological disorders: mechanisms, implications, and therapeutic potential.Frontiers in immunology · 2025
Review
Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis.Frontiers in pharmacology · 2025
Review
Integrating Spatial Multi-Omics and Machine Learning to Unravel the Role of PANoptosis in Bladder Cancer Prognosis and Immunotherapy Response.Oncology research · 2025
Article
Nucleic Acid Sensor-Mediated PANoptosis in Viral Infection.Viruses · 2024
Review

4 · The record

Corrections and comments

Comment on
NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs.2023

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elliott M BernardDepartment of Immunobiology, University of Lausanne, Lausanne, Switzerland.

Petr BrozDepartment of Immunobiology, University of Lausanne, Lausanne, Switzerland. Electronic address: petr.broz@unil.ch.

University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al.

Indexed as

HemePathogen-Associated Molecular Pattern MoleculesCell DeathHemolysisHumansImmunity, InnateInflammationIntracellular Signaling Peptides and ProteinsNecrosisHemeIntracellular Signaling Peptides and ProteinsNLRP12 protein, humanPathogen-Associated Molecular Pattern Molecules

Identifiers

PMID37541218

DOI10.1016/j.molcel.2023.07.005

OpenAlexW4385547064

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.