Evidence map›Paper›PMID 37542065›Full record

ArticleScientific reports2023

Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction.

Rebecca E Ruggiero-Ruff, Pedro A Villa, Sarah Abu Hijleh, Bryant Avalos, Nicholas V DiPatrizio, Sachiko Haga-Yamanaka, Djurdjica Coss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca E Ruggiero-RuffDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.
Pedro A VillaDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.
Sarah Abu HijlehDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.
Bryant AvalosDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.
Nicholas V DiPatrizioDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.
Sachiko Haga-YamanakaDepartment of Molecular, Cell, and Systems Biology, College of Natural and Agricultural Sciences, University of California, Riverside, Riverside, USA.
Djurdjica CossDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA. djurdjica.coss@ucr.edu.
University of California, Riverside · US

Funding

The Role of AP1 Family Members in Hormone Gene ExpressionR01HD091167 · NICHD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI COSS, DJURDJICA · 2018 to 2022
$1.7M
NICHD NIH HHS R01 HD091167
6 · The paper itself

Abstract

Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to Fragile X Syndrome, the most common monogenic cause of intellectual disability and autism. People affected with mutations in FMR1 have higher incidence of obesity, but the mechanisms are largely unknown. In the current study, we determined that male Fmr1 knockout mice (KO, Fmr1

Indexed as

Fragile X SyndromePro-OpiomelanocortinAnimalsBody WeightFragile X Messenger Ribonucleoprotein 1MaleMiceMice, KnockoutMutationObesityRibonucleoproteinsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1messenger ribonucleoproteinPro-OpiomelanocortinRibonucleoproteins

Identifiers

PMID37542065
PMCPMC10403586
OpenAlexW4385584261

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.