Evidence map›Paper›PMID 37542543›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis.

Ana Myriam Lavín-Pérez, Daniel Collado-Mateo, Shaghayegh Abbasi, João B Ferreira-Júnior, Amir Hossein Ahmadi Hekmatikar

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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  19. Correspondence: work smart or work hard in patients with metastatic breast cancer: emphasizing the importance of immunological and lactate changes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Ana Myriam Lavín-PérezCentre for Sport Studies, Rey Juan Carlos University, 28043 Fuenlabrada, Spain and GO fit LAB, Ingesport, 28003, Madrid, Spain.
Daniel Collado-MateoCentre for Sport Studies, Rey Juan Carlos University, Fuenlabrada, 28043, Spain. daniel.collado@urjc.es.
Shaghayegh AbbasiDepartment of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, 10600, Iran.
João B Ferreira-JúniorFederal Institute of Sudeste of Minas Gerais, Rio Pomba, 36180-000, Brazil.
Amir Hossein Ahmadi HekmatikarDepartment of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, 10600, Iran. a.hekmatikar4@gmail.com.
Universidad Rey Juan Carlos · ESInstituto Federal do Sudeste de Minas Gerais · BRKharazmi University · IRTarbiat Modares University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise is effective for improving the physical and psychological health of breast cancer patients. However, there is still controversy around its role on the immune system. Therefore, this systematic review and meta-analysis is aimed to evaluate the effect of chronic exercise on the number and activity of the immune cells that can contribute to anti-tumor immune responses, such as natural killers (NK) cells, CD + 4, or CD + 8. The main hypothesis of this study was that exercise could improve the immune system or, at least, there will not be a reduction in the number or activity of immune cells because of exercise. The search was conducted in the PubMed and Web of Science databases. Out of 244 studies reviewed, 10 studies met the inclusion criteria. The studies included in the meta-analyses showed mixed results and no significant (p > 0.05) positive or negative effects of exercise interventions in women with breast cancer. Therefore, the current evidence indicates that exercise does not significantly improve or reduce the immune system; thus, the prescription of exercise must not be discouraged due to the effects on the number and activity of immune system cells, but should be recommended due to the well-known benefits in quality of life, physical function or fatigue, and the absence of negative effects on the immune system. Further studies are needed to evaluate the effects according to the type of exercise, the type of cancer, or the timing of the intervention.

Indexed as

Breast NeoplasmsExerciseFemaleHumansMental HealthQuality of LifeSurvivorsAnd NK cellBreast cancerCD + 4CD + 8ExerciseImmune systemPhysical activity

Identifiers

PMID37542543
OpenAlexW4385607403

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.