Evidence map›Paper›PMID 37542910›Full record

ReviewCurrent opinion in structural biology2023

Solution NMR investigations of integral membrane proteins: Challenges and innovations.

Matthew Necelis, Connor McDermott, Meagan Belcher Dufrisne, Christopher Baryiames, Linda Columbus

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Future opportunities in solute carrier structural biology.Nature structural & molecular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew NecelisDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Connor McDermottDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Meagan Belcher DufrisneDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Christopher BaryiamesDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Linda ColumbusDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA. Electronic address: lc4zs@virginia.edu.
University of Virginia · US

Funding

Biophysical understanding of pathogen-host membrane protein interactions for drug discovery and deliveryR35GM131829 · NIGMS · UNIVERSITY OF VIRGINIA · PI Linda M Columbus · 2019 to 2026
$3.2M
Determining the role of lipooligosaccharide on the Opa structural ensemble and the formation of an Opa-CEACAM complexF32GM136076 · NIGMS · UNIVERSITY OF VIRGINIA · PI BELCHER DUFRISNE, MEAGAN LEIGH · 2020 to 2022
$203k
NIGMS NIH HHS F32 GM136076NIGMS NIH HHS R35 GM131829
6 · The paper itself

Abstract

Compared to soluble protein counterparts, the understanding of membrane protein stability, solvent interactions, and function are not as well understood. Recent advancements in labeling, expression, and stabilization of membrane proteins have enabled solution nuclear magnetic resonance spectroscopy to investigate membrane protein conformational states, ligand binding, lipid interactions, stability, and folding. This review highlights these advancements and new understandings and provides examples of recent applications.

Indexed as

Membrane ProteinsMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularProtein ConformationMembrane Proteins

Identifiers

PMID37542910
PMCPMC10529709
OpenAlexW4385549478

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.