Trial reportJournal of the International Society of Sports Nutrition2023
Effects of pre-sleep protein supplementation on plasma markers of muscle damage and inflammatory cytokines resulting from sprint interval training in trained swimmers.
Trial report in Journal of the International Society of Sports Nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis.Nutrients · 2024Pooled it
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-sleep protein has been shown to improve muscle recovery overnight following exercise-induced muscle damage. Whether such an approach affects recovery from sprint interval training (SIT) has yet to be elucidated. This study examined the effects of protein supplementation every night before sleep on early (45 min post-SIT) and late (24 and 48 h after SIT) responses of creatine kinase (CK) and inflammatory cytokines, including interleukin-6 and 10 (IL-6 and IL-10) and tumor necrosis factor-alpha (TNFα).
methodsTwenty trained swimmers underwent a 2-week in-water swimming SIT (two sets of 12 × 50-m all-out swims, interspersed by 1:1 recovery between each sprint and 3 min of rest between sets) and were randomized to two intervention groups receiving either 0.5 g kg
resultsCK concentrations elevated from resting point to 24 and 48 h post-SIT for both PRO and CHO groups (
conclusionsPre-sleep protein ingestion failed to ameliorate blood markers of muscle damage. The late anti-inflammatory profile of cytokines and exercise-induced muscle damage improved after two weeks of swimming SIT with either protein or carbohydrate ingestion before sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.