Evidence map›Paper›PMID 37544313›Full record

ArticleThe Lancet. Microbe2023

Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation.

Carolyn V Gould, Rebecca J Free, Julu Bhatnagar, Raymond A Soto, Tricia L Royer, Warren R Maley, Sean Moss, Matthew A Berk, Rebecca Craig-Shapiro, Rosy Priya L Kodiyanplakkal and 35 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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  10. A Scoping Review of Arthropod-Borne Flavivirus Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors at 18 institutions in 1 country.

Carolyn V GouldDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA. Electronic address: cgould@cdc.gov.
Rebecca J FreeDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Julu BhatnagarDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Raymond A SotoDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Tricia L RoyerDivision of Infectious Diseases, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Warren R MaleyDivision of Transplantation, Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Sean MossDivision of Infectious Diseases, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Matthew A BerkDepartment of Neurology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Rebecca Craig-ShapiroDivision of Transplant Surgery, Department of Surgery, Weill Cornell Medicine, New York, NY, USA.
Rosy Priya L KodiyanplakkalDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Lars F WestbladeDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Thangamani MuthukumarDivision of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Yoram A PuiusDivision of Infectious Diseases, Department of Medicine, Montefiore Medical Center, New York, NY, USA.
Amresh RainaSection of Advanced Heart Failure, Transplant, Mechanical Circulatory Support, and Pulmonary Hypertension, Cardiovascular Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.
Azam HadiSection of Advanced Heart Failure, Transplant, Mechanical Circulatory Support, and Pulmonary Hypertension, Cardiovascular Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.
Kymberly A GyureDepartment of Pathology and Laboratory Medicine, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.
Danielle TriefDepartment of Ophthalmology, Edward S Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.
Marcus PereiraTransplant Infectious Disease Program, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY, USA.
Matthew J KuehnertOffice of the Director, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; Hackensack Meridian School of Medicine, Hackensack, NJ, USA.
Vennus BallenBureau of Public Health Clinics, New York City Department of Health and Mental Hygiene, New York, NY, USA.
Debra A KesslerMedical Programs and Services, New York Blood Center, New York, NY, USA.
Kimberly DaileyDivision of Infectious Disease and Epidemiology, West Virginia Department of Health, Charleston, WV, USA.
Charles OmuraDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Thuy DoanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Steve MillerDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Michael R WilsonWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Jennifer A LehmanDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Jana M RitterDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Elizabeth LeeDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Luciana Silva-FlanneryDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sarah Reagan-SteinerDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jason O VelezDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Janeen J LavenDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Kelly A FitzpatrickDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Amanda PanellaDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Emily H DavisDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Holly R HughesDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Aaron C BraultDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Kirsten St GeorgeLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Science, Graduate School of Public Health, State University of New York at Albany, Albany, NY, USA.
Amy B DeanLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Joel AckelsbergBureau of Communicable Diseases, New York City Department of Health and Mental Hygiene, New York, NY, USA.
Sridhar V BasavarajuDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Charles Y ChiuDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
J Erin StaplesDivision of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Yellow Fever Vaccine Virus Transplant and Transfusion Investigation Team
National Center for Emerging and Zoonotic Infectious Diseases · USCenters for Disease Control and Prevention · USUniversity of California, San Francisco · USThomas Jefferson University · USAllegheny General Hospital · USCornell University · USNew York City Department of Health and Mental Hygiene · USOffice of the Director · USWeill Cornell Medicine · USAllegheny Health Network · USColumbia University · USColumbia University Irving Medical Center · USEpidemic Intelligence Service · USMontefiore Medical Center · USNew York Blood Center · USUniversity at Albany, State University of New York · USVirginia Department of Health · USWadsworth Center · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundIn 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. We describe an investigation into the cause of encephalitis in these patients.

methodsFrom Nov 7, 2021, to Feb 24, 2022, we conducted a public health investigation involving 15 agencies and medical centres in the USA. We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor.

findingsWe identified one read from yellow fever virus in cerebrospinal fluid from the recipient of a kidney using metagenomic next-generation sequencing. Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. Two patients recovered and two patients had no neurological recovery and died. 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation.

interpretationThis investigation substantiates the use of metagenomic next-generation sequencing for the broad-based detection of rare or unexpected pathogens. Health-care workers providing vaccinations should inform patients of the need to defer blood donation for at least 2 weeks after receiving a yellow fever vaccine. Despite mitigation strategies and safety interventions, a low risk of transfusion-transmitted infections remains.

fundingUS Centers for Disease Control and Prevention (CDC), the Biomedical Advanced Research and Development Authority, and the CDC Epidemiology and Laboratory Capacity Cooperative Agreement for Infectious Diseases.

Indexed as

EncephalitisOrgan TransplantationYellow Fever VaccineBlood TransfusionHumansUnited StatesYellow fever virusYellow Fever Vaccine

Identifiers

PMID37544313
PMCPMC11089990
OpenAlexW4385516486

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.