Evidence map›Paper›PMID 37545491›Full record

ArticleFrontiers in immunology2023

EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells.

Vinicio Melo, Levi Collin Nelemans, Martijn Vlaming, Harm Jan Lourens, Valerie R Wiersma, Vrouyr Bilemjian, Gerwin Huls, Marco de Bruyn, Edwin Bremer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vinicio MeloDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Levi Collin NelemansDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Martijn VlamingDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Harm Jan LourensDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Valerie R WiersmaDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Vrouyr BilemjianDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Gerwin HulsDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Marco de BruynDepartment of Obstetrics & Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Edwin BremerDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A higher density of tumor infiltrating lymphocytes (TILs) in the tumor microenvironment, particularly cytotoxic CD8

Indexed as

Antibodies, BispecificNeoplasmsCD8-Positive T-LymphocytesErbB ReceptorsHumansSignal TransductionTumor MicroenvironmentAntibodies, BispecificEGFR protein, humanErbB Receptorsbispecific antibodyCD27co-stimulationEGFRimmunotherapyT cell

Identifiers

PMID37545491
PMCPMC10399592

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.