Evidence map›Paper›PMID 37546804›Full record

ArticleResearch square2023

MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing.

Rong Zhai, Kai Ruan, German Farinas Perez, Miroslav Kubat, Jiaqi Liu, Ivo Hofacker, Stefan Wuchty

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rong ZhaiUniversity of Miami.ORCID 0000-0002-7599-1430
Kai RuanUniversity of Miami, Miller School of Medicine.ORCID 0000-0002-3399-1862
German Farinas PerezUniversity of Miami.ORCID 0000-0001-7853-0747
Miroslav KubatUniversity of Miami.
Jiaqi LiuUniversity of Miami Miller School of Medicine.
Ivo HofackerUniversitaet Wien.ORCID 0000-0001-7132-0800
Stefan WuchtyUniversity of Miami.
University of Miami · US

Funding

1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omicsR01MH117293 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2018 to 2026
$4.3M
Genomic Studies in Charcot-Marie-Tooth DiseaseR01NS105755 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHY, MICHAEL E., ZUCHNER, STEPHAN · 2019 to 2023
$3.2M
microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic PainR33AT010408 · NCCIH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHAI, RONG GRACE · 2022 to 2024
$2.1M
NCCIH NIH HHS R33 AT010408NIMH NIH HHS R01 MH117293NINDS NIH HHS R01 NS105755
6 · The paper itself

Abstract

While RNA secondary structures are critical to regulate alternative splicing of long-range pre-mRNA, the factors that modulate RNA structure and interfere with the recognition of the splice sites are largely unknown. Previously, we identified a small, non-coding microRNA that sufficiently affects stable stem structure formation of

Identifiers

PMID37546804
PMCPMC10402249
OpenAlexW4385334913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.