Evidence map›Paper›PMID 37546914›Full record

ArticleResearch square2023

CYP5122A1 encodes an essential sterol C4-methyl oxidase in

Yiru Jin, Somrita Basu, Mei Feng, Yu Ning, Indeewara Munasinghe, Arline M Joachim, Junan Li, Robert Madden, Hannah Burks, Philip Gao and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yiru JinDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.
Somrita BasuDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Mei FengDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.
Yu NingDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Indeewara MunasingheSynthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS 66047, USA.
Arline M JoachimDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Junan LiCollege of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
Robert MaddenDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Hannah BurksDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Philip GaoProtein Production Group, The University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0001-9741-9390
Chamani PereraSynthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS 66047, USA.
Karl A WerbovetzDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Kai ZhangDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Michael Zhuo WangDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0003-2494-4172
University of Kansas · USTexas Tech University · USThe Ohio State University · US

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
Identification of CYP5122A1 inhibitors as chemical probes for Leishmania biologyR01AI139198 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI WANG, ZHUO MICHAEL · 2019 to 2022
$2.1M
Phospholipid metabolism in LeishmaniaR15AI156746 · NIAID · TEXAS TECH UNIVERSITY · PI ZHANG, KAI · 2021 to 2024
$959k
NIAID NIH HHS R01 AI139198NIAID NIH HHS R15 AI156746NIGMS NIH HHS P20 GM113117NIGMS NIH HHS P30 GM110761NIGMS NIH HHS P30 GM145499
6 · The paper itself

Abstract

Visceral leishmaniasis, caused by

Identifiers

PMID37546914
PMCPMC10402201
OpenAlexW4385303439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.