Evidence map›Paper›PMID 37547183›Full record

ArticleOsteoarthritis and cartilage open2023

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α.

Ermina Hadzic, Bethia To, Michael A Pest, Ling Qin, Frank Beier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ermina HadzicDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, ON, Canada.
Bethia ToDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, ON, Canada.
Michael A PestDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, ON, Canada.
Ling QinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Frank BeierDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, ON, Canada.
Western University · CAUniversity of Pennsylvania · US

Funding

EGFR signaling in osteoarthritis and treatmentR01AG067698 · NIA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2020 to 2024
$2.3M
NIA NIH HHS R01 AG067698
6 · The paper itself

Abstract

Background/objective: Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development and its ligand transforming growth factor- Methods: We generated double knockout mice by crossing cartilage-specific Results: Mig-6 deficient mice display cartilage thickening and CONs at 12 weeks in both the elbow and knee joints, which is independent of TGF Conclusion: The articular cartilage displays increased thickness/cell density and CON formation independent of the presence of TGF

Indexed as

Animal modelChondrocyteEpidermal growth factor receptorMitogen inducible gene 6Transforming growth factor-alphaTransgenic mice

Identifiers

PMID37547183
PMCPMC10400912
OpenAlexW4385310002

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.