Evidence map›Paper›PMID 37548452›Full record

ArticlemBio2023

Functional screening reveals

Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  11. TheeLife · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Qiang-Qiang Wang *National Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.ORCID 0000-0001-5236-5421
Ming Sun *National Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Tao Tang *National Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
De-Hua Lai *MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou, China.
Jing LiuNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Sanjay MaityDepartment of Chemistry, University of Minnesota , Minneapolis, Minnesota, USA.
Kai HeNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Xi-Ting WuNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Jiong YangMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou, China.
Yue-Bao LiNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Xiao-Yan TangNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Hui-Yong DingNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.
Geoff HideBiomedical Research and Innovation Centre and Environmental Research and Innovation Centre, School of Science, Engineering and Environment, University of Salford , Salford, United Kingdom.
Mark DistefanoDepartment of Chemistry, University of Minnesota , Minneapolis, Minnesota, USA.
Zhao-Rong LunMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou, China.
Xing-Quan ZhuCollege of Veterinary Medicine, Shanxi Agricultural University , Jinzhong, Shanxi Province, China.ORCID 0000-0003-2530-4628
Shaojun LongNational Key Laboratory of Veterinary Public Health Security and College of Veterinary Medicine, China Agricultural University , Beijing, China.ORCID 0000-0002-5409-2831
China Agricultural University · CNSun Yat-sen University · CNUniversity of Minnesota · USShanxi Agricultural University · CNUniversity of Salford · GB

Funding

Chemical Approaches for Exploring Protein Prenylation in Living CellsR35GM141853 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARK D DISTEFANO · 2021 to 2026
$2.4M
NIGMS NIH HHS R35 GM141853
6 · The paper itself

Abstract

In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying endocytic trafficking remains elusive, due to the repurposing of classical endocytic proteins for the biogenesis of apical organelles. To resolve this issue, we have exploited the genetic tractability of the model apicomplexan

Indexed as

ToxoplasmaEndosomesGreen Fluorescent ProteinsProtein TransportProteomeProtozoan ProteinsGreen Fluorescent ProteinsProteomeProtozoan Proteinsapicomplexansdigestive vacuoleendocytic traffickingmalaria parasitesprenylomeprotein prenylationrhoptry biogenesissecretory traffickingToxoplasma gondii

Identifiers

PMID37548452
PMCPMC10470541
OpenAlexW4385620996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.