Evidence map›Paper›PMID 37548881›Full record

ArticleGeroScience2024

Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease.

Loretta Zsuzsa Kiss, Balázs Bence Nyárády, Éva Pállinger, Árpád Lux, Ádám Levente Jermendy, Csaba Csobay-Novák, Pál Soós, Zsolt Szelid, Orsolya Láng, László Kőhidai and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Loretta Zsuzsa KissHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary. kisslotti@gmail.com.ORCID 0000-0002-9209-3552
Balázs Bence NyárádyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Éva PállingerDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, 1089, Budapest, Hungary.
Árpád LuxHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Ádám Levente JermendyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Csaba Csobay-NovákHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Pál SoósHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Zsolt SzelidHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Orsolya LángDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, 1089, Budapest, Hungary.
László KőhidaiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, 1089, Budapest, Hungary.
Elek DinyaInstitute of Digital Health Sciences, Semmelweis University, 15 Ferenc Square, 1094, Budapest, Hungary.
Edit DósaHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Zsolt BagyuraHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Semmelweis University · HU

Funding

European Union RRF-2.3.1-21-2022-00003Ministry of Innovation and Technology, Hungary TKP2021-NVA-15National Research, Development and Innovation Office NVKP_16-1-2016-0017
6 · The paper itself

Abstract

Growth and differentiation factor-15 (GDF-15) is a stress-associated cytokine of the transforming growth factor-β superfamily. The inflammatory and angiogenic effects of GDF-15 in atherosclerosis are controversial, and its correlation with the long asymptomatic phase of the disease is not well understood. Coronary artery calcium score (CACS) and ankle-brachial index (ABI) are sensitive markers of subclinical atherosclerosis. To date, only a few studies have examined the impact of GDF-15 on coronary artery calcification, and the association between GDF-15 and ABI has not been evaluated. Therefore, we aimed to investigate the possible relationship between serum GDF-15 concentrations and CACS and ABI in a Caucasian population sample of middle-aged (35-65 years) and elderly (> 65 years) people. In addition to recording demographic and anthropometric characteristics, atherosclerotic risk factors, and laboratory tests including serum HDL-cholesterol, LDL-cholesterol, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein, and N-terminal pro-B-type natriuretic peptide (NT-proBNP); GDF-15 level, cardiac computed tomography, and ABI measurements were also performed. A total of 269 asymptomatic individuals (men, n = 125; median age, 61.5 [IQR, 12.7] years) formed the basis of this study. Participants were divided into two groups according to their age (middle-aged, n = 175 and elderly, n = 94). Hypertension and diabetes mellitus were significantly more prevalent and CACS values and HbA1c, NT-proBNP, and GDF-15 levels were significantly higher (all p < 0.001) in the elderly group compared to the middle-aged group. Multivariate ridge regression analysis revealed a significant positive association between GDF-15 and CACS (middle-aged group: β = 0.072, p = 0.333; elderly group: β = 0.148, p = 0.003), and between GDF-15 and ABI (middle-aged group: β = 0.062, p = 0.393; elderly group: β = 0.088, p = 0.041) only in the elderly group. Our results show that GDF-15 is not only a useful biomarker of inflammation but can also predict early signs of asymptomatic atherosclerosis, especially in elderly people with chronic systemic inflammation associated with aging (inflammaging).

Indexed as

AtherosclerosisCardiovascular DiseasesAgedAnkle Brachial IndexCalciumCoronary VesselsGlycated HemoglobinGrowth Differentiation Factor 15HumansInflammationMaleMiddle AgedCalciumGlycated HemoglobinGrowth Differentiation Factor 15AgingAnkle-brachial indexAtherosclerosisCardiovascular risk factorsCoronary artery calcium scoreGrowth and differentiation factor-15Inflammaging

Identifiers

PMID37548881
PMCPMC10828406
OpenAlexW4385619725

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.