Evidence map›Paper›PMID 37549805›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2023

Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization.

Bright Obeng, Christian M Potts, Bailey E West, John E Burnell, Patrick J Fleming, Juyoung K Shim, Marissa S Kinney, Emily L Ledue, Suraj Sangroula, Alan Y Baez Vazquez and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Antimicrobial cetylpyridinium chloride causes functional inhibition of mitochondria as potently as canonical mitotoxicants, nanostructural disruption of mitochondria, and mitochondrial CaFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bright ObengDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Christian M PottsDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Bailey E WestDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
John E BurnellDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Patrick J FlemingDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Juyoung K ShimDepartment of Biology, University of Maine Augusta, Augusta, ME, USA.
Marissa S KinneyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Emily L LedueDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Suraj SangroulaDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Alan Y Baez VazquezDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Julie A GosseDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA. Electronic address: julie.gosse@maine.edu.
University of Maine · USUniversity of Maine at Augusta · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Mechanisms of cetylpyridinium chloride inhibition of immune cell functionR15ES034567 · NIEHS · UNIVERSITY OF MAINE ORONO · PI GOSSE, JULIE ANN · 2022 to 2022
$426k
NIEHS NIH HHS R15 ES034567NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

Cetylpyridinium chloride (CPC) is an antimicrobial used in numerous personal care and janitorial products and food for human consumption at millimolar concentrations. Minimal information exists on the eukaryotic toxicology of CPC. We have investigated the effects of CPC on signal transduction of the immune cell type mast cells. Here, we show that CPC inhibits the mast cell function degranulation with antigen dose-dependence and at non-cytotoxic doses ∼1000-fold lower than concentrations in consumer products. Previously we showed that CPC disrupts phosphatidylinositol 4,5-bisphosphate, a signaling lipid critical for store-operated Ca

Indexed as

CetylpyridiniumMast CellsCalciumCalcium SignalingHumansPharmaceutical PreparationsSignal TransductionCalciumCetylpyridiniumPharmaceutical PreparationsAntimicrobialCalciumCetylpyridinium chlorideCytoplasmic pHDegranulationEndoplasmic reticulumInositol 1,4,5-triphosphateMast cellMicrotubulePlasma membrane potentialQuaternary ammonium compound

Identifiers

PMID37549805
PMCPMC10529140
OpenAlexW4385614629

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.