Evidence map›Paper›PMID 37551173›Full record

ArticleIranian journal of public health2023

Accelerated Apoptosis and Down-Regulated FMRP in Human Neuroblastoma Cells with CRISPR/

Rong Zhang, Huifen Xu, Jin Lu, Ying Chen, Yahui Zhang, Li Xiao

Abstract read
In one paragraph

Article in Iranian journal of public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in aProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rong ZhangDepartment of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Huifen XuDepartment of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310057, China.
Jin LuDepartment of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Ying ChenDepartment of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Yahui ZhangDepartment of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Li XiaoDepartment of Gynecology and Obstetrics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fragile X syndrome (FXS) is a genetic disease with intellectual disabilities. FXS is often caused by the CGG-repeat expansion mutation in the Methods: PCR and DNA clone were used to construct plasmids. CRISPR function was tested by Western blot and flow cytometry. Data were analyzed by a two-tailed unpaired Student's Results: Cell cycle analysis showed significant differences in G1, S and G2/M phases between the two groups ( Conclusion: This study provides further understanding about the FMRP function and molecular mechanism of

Indexed as

CRISPR associated protein 9Fragile X syndromesGene editing

Identifiers

PMID37551173
PMCPMC10404333

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.