Evidence map›Paper›PMID 37553306›Full record

ArticleDiscovery medicine2023

Macula Densa Nitric Oxide Synthase 1 Controls Renin Release and Renin-Dependent Blood Pressure Changes.

Catherine Liu, Ximing Wang, Colby Parris, Qi Pang, Muhammad Usman Naeem, Lei Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discovery medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Catherine LiuDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33620, USA.
Ximing WangDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33620, USA.
Colby ParrisDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33620, USA.
Qi PangDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Muhammad Usman NaeemDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33620, USA.
Lei WangDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33620, USA.
Florida College · USUniversity of South Florida · USWayne State University · US

Funding

Macula densa NOS1 and transplanted renal graft functionR01DK122050 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LEI · 2020 to 2024
$1.6M
Protection of donor kidneys with synchronization modulation electric field (SMEF)R41DK130764 · NIDDK · WR BIOTECH, LLC · PI CHEN, WEI, LIU, RUISHENG · 2021 to 2021
$251k
NIDDK NIH HHS R01 DK122050NIDDK NIH HHS R41 DK130764
6 · The paper itself

Abstract

backgroundThe function of macula densa nitric oxide synthase 1 (NOS1) in the regulation of renin release is controversial. This study was conducted to further elucidate the role of macula densa NOS1 in renin release and blood pressure regulation in response to salt challenges and hemorrhagic shock.

methodsTo investigate the specific role of NOS1 in the macula densa within the kidney in response to varying sodium concentrations in the diet, tissue macula densa-specific NOS1 knockout (MD-NOS1KO) and wild type (WT) mice were subjected to sequential low (0.1% NaCl) and high (1.4% NaCl) sodium diets. Separate groups of mice, consisting of both MD-NOS1KO subgroup and WT subgroup, were induced hemorrhagic shock by retro-orbital bleeding of 12 mL blood/kg body weight. Mean arterial pressure (MAP) was measured by a radio-telemetry system. Plasma renin concentration (PRC) was measured with the radioimmunoassay for both sodium diet and hemorrhagic shock experiments.

resultsPRCs were 371 ± 95 and 411 ± 68 ng/mL/hr in WT and MD-NOS1KO mice fed a normal sodium diet, respectively. Low salt intake stimulated an increase in the renin release by about 260% in WT mice (PRC = 1364 ± 217 ng/mL/hr,

conclusionsOur study demonstrated that macula densa NOS1 plays an important role in mediating renin release. This mechanism is essential in maintaining blood pressure under hypovolemic situations such as hemorrhagic shock.

Indexed as

ReninShock, HemorrhagicAnimalsBlood PressureMiceSodiumSodium ChlorideSodium Chloride, DietaryReninSodiumSodium ChlorideSodium Chloride, Dietaryhemorrhagic shockmacula densa nitric oxide synthase 1renin release

Identifiers

PMID37553306
PMCPMC10921921
OpenAlexW4385467031

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.