Evidence map›Paper›PMID 37555826›Full record

ArticleeLife2023

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton.

Daniel A Kramer, Heidy Y Narvaez-Ortiz, Urval Patel, Rebecca Shi, Kang Shen, Brad J Nolen, Julien Roche, Baoyu Chen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. mBio · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Daniel A KramerRoy J Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, United States.ORCID 0000-0002-7159-9562
Heidy Y Narvaez-OrtizDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, United States.
Urval PatelRoy J Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, United States.
Rebecca ShiDepartment of Biology, Stanford University, Stanford, United States.
Kang ShenDepartment of Biology, Stanford University, Stanford, United States.ORCID 0000-0003-4059-8249
Brad J NolenDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, United States.ORCID 0000-0002-0224-9980
Julien RocheRoy J Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, United States.ORCID 0000-0003-1254-1173
Baoyu ChenRoy J Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, United States.ORCID 0000-0002-6366-159X
Iowa State University · USUniversity of Oregon · USHoward Hughes Medical Institute · USNeurosciences Institute · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Control of actin filament networks by Arp2/3 complex and its regulatorsR35GM136319 · NIGMS · UNIVERSITY OF OREGON · PI Bradley J Nolen · 2020 to 2026
$4.4M
Patterning dendritic branches with environmental and neuronal surface moleculesR01NS082208 · NINDS · STANFORD UNIVERSITY · PI KANG SHEN · 2013 to 2026
$4.1M
Signal Integration from Membranes to the Actin CytoskeletonR35GM128786 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Baoyu Chen · 2018 to 2026
$3.6M
Structure and function of DISC1 in the cAMP pathwayR01GM132561 · NIGMS · IOWA STATE UNIVERSITY · PI ROCHE, JULIEN · 2019 to 2023
$1.6M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM132561NIGMS NIH HHS R35 GM128786NIGMS NIH HHS R35 GM136319NIH HHS R01 GM132561NIH HHS R35 GM136319NIMH NIH HHS T32 MH020016NINDS NIH HHS R01 NS082208
6 · The paper itself

Abstract

Dendrite morphogenesis is essential for neural circuit formation, yet the molecular mechanisms underlying complex dendrite branching remain elusive. Previous studies on the highly branched

Indexed as

Actin CytoskeletonActinsActin-Related Protein 2-3 ComplexAnimalsCaenorhabditis elegansCarrier ProteinsDendritesMembrane ProteinsActin-Related Protein 2-3 ComplexActinsCarrier ProteinsMembrane Proteinsactin cytoskeletonArp2/3 complexbiochemistrycapping proteinC. eleganschemical biologydendrite branchingE. colihumanintrinsically disordered proteinmolecular biophysicsneuronal receptorstructural biology

Identifiers

PMID37555826
PMCPMC10411975
OpenAlexW4385684637

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.