Evidence map›Paper›PMID 37557925›Full record

ArticleBioorganic & medicinal chemistry letters2023

Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase.

Mukund Tantak, Ramanjaneyulu Rayala, Zifang Deng, Ashley Bunnell, Ting Wang, Prakash Chaudhari, Fenfei Leng, Adel Nefzi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mukund TantakCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Ramanjaneyulu RayalaCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Zifang DengDepartment of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Ashley BunnellCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Ting WangCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Prakash ChaudhariCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
Fenfei LengDepartment of Chemistry & Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Adel NefziCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA; Herbert Wertheim College of Medicine, FIU, 11200 SW 8th St, Miami, FL 33199, USA. Electronic address: anefzi@fiu.edu.
Florida International University · US

Funding

Targeting transcription-coupled DNA supercoiling for discovering antibiotics against bacterial DNA gyraseR21AI125973 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI · 2017 to 2018
$478k
High throughput screening for anti-adhesion drugs against placental and cerebral malariaR21AI137721 · NIAID · FLORIDA ATLANTIC UNIVERSITY · PI NEFZI, ADEL, OLEINIKOV, ANDREW V · 2018 to 2019
$476k
Novel gyrase inhibitors targeting Mycobacterium tuberculosisR21AI178134 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI, NEFZI, ADEL · 2023 to 2024
$422k
NIAID NIH HHS R21 AI125973NIAID NIH HHS R21 AI137721NIAID NIH HHS R21 AI178134
6 · The paper itself

Abstract

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields. We report the design and the parallel synthesis of novel linear oligocyclic guanidine peptidomimetics from predesigned reduced polyamides. A screening of these compounds identified active Mycobacterium tuberculosis DNA gyrase inhibitors which do not inhibit human DNA topoisomerase IIα and topoisomerase I.

Indexed as

Mycobacterium tuberculosisPeptidomimeticsTuberculosisDNA GyraseGuanidineGuanidinesHumansSolid-Phase Synthesis TechniquesTopoisomerase II InhibitorsDNA GyraseGuanidineGuanidinesPeptidomimeticsTopoisomerase II Inhibitors

Identifiers

PMID37557925
PMCPMC10993493
OpenAlexW4385623661

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.