Evidence map›Paper›PMID 37559849›Full record

ArticleCureus2023

Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report.

Harkaran S Rana, Jake E Dertinger, Carson Clabeaux, Nicole Makepeace, Jason Lewis

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Harkaran S RanaOphthalmology, Walter Reed National Military Medical Center, Bethesda, USA.
Jake E DertingerOphthalmology, California Health Sciences University College of Osteopathic Medicine, Clovis, USA.
Carson ClabeauxOphthalmology, Madigan Army Medical Center, Bethesda, USA.
Nicole MakepeaceOphthalmology, Walter Reed National Military Medical Center, Bethesda, USA.
Jason LewisOphthalmology, Walter Reed National Military Medical Center, Bethesda, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radiographically and intraoperatively, the sub-brow mass communicated with the intraorbital mass via perineural spread along the supraorbital nerve. Histopathology confirmed the diagnosis of melanoma based on the melanocytic markers, SOX-10 and Melan-A; dedifferentiation was demonstrated within the orbital tumor. Two weeks following surgical debulking, the intraorbital mass returned to its full size. Local radiotherapy and immunotherapy were performed, which initially led to a dramatic improvement; however, the patient succumbed to his systemic metastases six months later. Dedifferentiation serves as a prognostic indicator and should be considered in patients when histopathology does not lead to a definitive diagnosis.

Indexed as

intraorbital massmetastatic melanomaorbital metastasesorbital tumorpalliative debulking of tumorperineurial spread

Identifiers

PMID37559849
PMCPMC10408357

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.