Evidence map›Paper›PMID 37560072›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2023

The Clinical Utility of Post-Transplant Monitoring of Donor-Specific Antibodies in Stable Renal Transplant Recipients: A Consensus Report With Guideline Statements for Clinical Practice.

Dennis A J van den Broek, Soufian Meziyerh, Klemens Budde, Carmen Lefaucheur, Emanuele Cozzi, Dominique Bertrand, Covadonga López Del Moral, Anthony Dorling, Marie-Paule Emonds, Maarten Naesens and 2 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 32 citations in OpenAlex.

  1. Donor-derived cell-free DNA monitoring for early diagnosis of antibody-mediated rejection after kidney transplantation: a randomized trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Trial
  2. Article
  3. Review
  4. Review
  5. Tailoring HLA antibody monitoring post-transplantation.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. PreformedWorld journal of transplantation · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Turkish journal of surgery · 2025
    Article
  17. Noninvasive Diagnosis of Kidney Allograft Rejection.Journal of the American Society of Nephrology : JASN · 2025
    Review
  18. Article
  19. Review
  20. Antibody-mediated rejection-treatment standard.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 6 countries.

Dennis A J van den BroekDivision of Nephrology, Department of Medicine, Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Soufian MeziyerhDivision of Nephrology, Department of Medicine, Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Klemens BuddeDepartment of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
Carmen LefaucheurParis Translational Research Center for Organ Transplantation, Kidney Transplant Department, Saint Louis Hospital, Université de Paris Cité, Paris, France.
Emanuele CozziDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health, Transplant Immunology Unit, Padua University Hospital, Padua, Italy.
Dominique BertrandDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Covadonga López Del MoralDepartment of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
Anthony DorlingDepartment of Inflammation Biology, Centre for Nephrology, Urology and Transplantation, School of Immunology & Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom.
Marie-Paule EmondsHistocompatibility and Immunogenetics Laboratory (HILA), Belgian Red Cross-Flanders, Mechelen, Belgium.
Maarten NaesensDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Aiko P J de VriesDivision of Nephrology, Department of Medicine, Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
ESOT Working Group Subclinical DSA Monitoring
KU Leuven · BECentre for Inflammation Research · GBCharité - Universitätsmedizin Berlin · DEInstituto de Investigación Marqués de Valdecilla · ESTranslational Research in Oncology · FRUniversité de Rouen Normandie · FRUniversity of Padua · IT

Funding

Medical Research Council MR/T025573/1
6 · The paper itself

Abstract

Solid phase immunoassays improved the detection and determination of the antigen-specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The widespread use of SPI in kidney transplantation also introduced new clinical dilemmas, such as whether patients should be monitored for DSA pre- or post-transplantation. Pretransplant screening through SPI has become standard practice and DSA are readily determined in case of suspected rejection. However, DSA monitoring in recipients with stable graft function has not been universally established as standard of care. This may be related to uncertainty regarding the clinical utility of DSA monitoring as a screening tool. This consensus report aims to appraise the clinical utility of DSA monitoring in recipients without overt signs of graft dysfunction, using the Wilson & Junger criteria for assessing the validity of a screening practice. To assess the evidence on DSA monitoring, the European Society for Organ Transplantation (ESOT) convened a dedicated workgroup, comprised of experts in transplantation nephrology and immunology, to review relevant literature. Guidelines and statements were developed during a consensus conference by Delphi methodology that took place in person in November 2022 in Prague. The findings and recommendations of the workgroup on subclinical DSA monitoring are presented in this article.

Indexed as

Kidney TransplantationOrgan TransplantationGraft RejectionGraft SurvivalHistocompatibility TestingHLA AntigensHumansIsoantibodiesKidneyPractice Guidelines as TopicRetrospective StudiesTissue DonorsTransplant RecipientsHLA AntigensIsoantibodiesbiomarkerdonor-specific HLA antibodiesDSAguidelinesmonitoringsubclinical rejection

Identifiers

PMID37560072
PMCPMC10408721
OpenAlexW4385237772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.