Evidence map›Paper›PMID 37561625›Full record

ArticleCell reports2023

Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells.

Priyanka Mishra, Alexander Silva, Jay Sharma, Jacqueline Nguyen, Donald P Pizzo, Denise Hinz, Debashis Sahoo, Stephanie Cherqui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Hematopoietic Stem-Cell Gene Therapy for Cystinosis.The New England journal of medicine · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Priyanka MishraDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Alexander SilvaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jay SharmaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Jacqueline NguyenDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Donald P PizzoDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Denise HinzFlow Cytometry Core Facility, La Jolla Institute for Immunology, La Jolla, CA, USA.
Debashis SahooDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California, La Jolla, La Jolla, CA, USA; Moores Comprehensive Cancer Center, University of California, La Jolla, La Jolla, CA, USA.
Stephanie CherquiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA. Electronic address: scherqui@ucsd.edu.
University of California San Diego · USLa Jolla Institute for Immunology · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Hematopoietic Stem Cell Gene Therapy for Friedreich's ataxiaR01NS108965 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERQUI, STEPHANIE · 2018 to 2022
$1.7M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS108965
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most prevalent cause of dementia; microglia have been implicated in AD pathogenesis, but their role is still matter of debate. Our study showed that single systemic wild-type (WT) hematopoietic stem and progenitor cell (HSPC) transplantation rescued the AD phenotype in 5xFAD mice and that transplantation may prevent microglia activation. Indeed, complete prevention of memory loss and neurocognitive impairment and decrease of β-amyloid plaques in the hippocampus and cortex were observed in the WT HSPC-transplanted 5xFAD mice compared with untreated 5xFAD mice and with mice transplanted with 5xFAD HSPCs. Neuroinflammation was also significantly reduced. Transcriptomic analysis revealed a significant decrease in gene expression related to "disease-associated microglia" in the cortex and "neurodegeneration-associated endothelial cells" in the hippocampus of the WT HSPC-transplanted 5xFAD mice compared with diseased controls. This work shows that HSPC transplant has the potential to prevent AD-associated complications and represents a promising therapeutic avenue for this disease.

Indexed as

Alzheimer DiseaseHematopoietic Stem Cell TransplantationAmyloid beta-PeptidesAnimalsDisease Models, AnimalEndothelial CellsMiceMice, TransgenicMicrogliaPhenotypeAmyloid beta-PeptidesAlzheimer's diseaseCP: NeuroscienceCP: Stem cell researchhematopoietic stem and and progenitor cellsmicrogliosisneuroinflammation

Identifiers

PMID37561625
PMCPMC10617121
OpenAlexW4385652098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.