Evidence map›Paper›PMID 37562117›Full record

ArticleEuropean journal of medicinal chemistry2023

Structure activity relationships of 5-HT

Dilip K Tosh, Maggie M Calkins, Marko S Ivancich, Hailey A Bock, Ryan G Campbell, Sarah A Lewicki, Eric Chen, Zhan-Guo Gao, John D McCorvy, Kenneth A Jacobson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  3. DualACS medicinal chemistry letters · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dilip K ToshMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Maggie M CalkinsMedical College of Wisconsin, Department of Cell Biology, Neurobiology, and Anatomy, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Marko S IvancichMedical College of Wisconsin, Department of Cell Biology, Neurobiology, and Anatomy, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Hailey A BockMedical College of Wisconsin, Department of Cell Biology, Neurobiology, and Anatomy, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Ryan G CampbellMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Sarah A LewickiMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Eric ChenMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
John D McCorvyMedical College of Wisconsin, Department of Cell Biology, Neurobiology, and Anatomy, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: kennethj@niddk.nih.gov.
National Institutes of Health · USMedical College of Wisconsin · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Molecular Mechanisms of G protein-coupled Receptor Biased SignalingR35GM133421 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2019 to 2026
$3.3M
Intramural NIH HHS ZIA DK031117NIGMS NIH HHS R35 GM133421
6 · The paper itself

Abstract

(N)-Methanocarba adenosine derivatives were structurally modified to target 5-HT

Indexed as

AdenosineSerotoninReceptor, Serotonin, 5-HT2BReceptors, Purinergic P1Serotonin AntagonistsStructure-Activity RelationshipAdenosine(N)-methanocarba-adenosineReceptor, Serotonin, 5-HT2BReceptors, Purinergic P1SerotoninSerotonin AntagonistsAdenosine receptorFunctional antagonismG protein-coupled receptorMethanocarbaNucleosidesRadioligand bindingScaffold repurposingSerotonin 5-HT(2B) receptorSerotonin receptorStructure activity relationship

Identifiers

PMID37562117
PMCPMC10529765
OpenAlexW4385399914

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.