ArticleJournal of epidemiology and community health2023
High levels of high-sensitivity C reactive protein to albumin ratio can increase the risk of cardiovascular disease.
Article in Journal of epidemiology and community health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- C-reactive protein-to-albumin ratio and the mortality of patients with heart failure: a meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Article
- Long-Term Outcomes After Percutaneous Coronary Intervention According to the High-Sensitivity C-Reactive Protein-to-Albumin Ratio in Patients With Chronic Obstructive Pulmonary Disease in China.Reviews in cardiovascular medicine · 2026Article
- The negative association between C-reactive protein-albumin-lymphocyte index and cardiovascular disease.The Journal of international medical research · 2026Article
- Integrating Inflammation and Lipid Metabolism Biomarkers for Early Risk Stratification in Acute Cerebral Infarction: A Nomogram-Based Approach.Mediators of inflammation · 2026Article
- Joint Associations of High-Sensitivity C-Reactive Protein and Albumin with Incident Heart Failure: A Prospective Cohort Study.Journal of inflammation research · 2026Article
- Article
- Association of C-reactive protein to albumin ratio with prevalence and mortality in metabolic syndrome: NHANES 1999-2010.European journal of medical research · 2025Article
- Association between serum albumin levels and risk of deep vein thrombosis in diabetic patients: a retrospective case-control study.Hormones (Athens, Greece) · 2025Article
- Prognostic value of the C-reactive protein-to-albumin ratio in acute decompensated heart failure across different glucose metabolism statuses.Scientific reports · 2025Article
- Identification of Candidate Inflammatory-Nutritional Blood Biomarkers for Cachexia and Muscle Depletion in Polish Chronic Heart Failure Patients.Journal of cardiovascular translational research · 2025Article
- Prognostic implications of the high sensitivity C-reactive protein to albumin ratio for major cardiovascular adverse events in patients undergoing noncardiac surgery.Scientific reports · 2025Article
- C-reactive protein-to-albumin ratio is associated with mortality after transcatheter tricuspid valve repair.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension.BMC pediatrics · 2025Article
- The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study.BMC public health · 2025Observational
- Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study.BMC pulmonary medicine · 2025Article
- The comprehensive effects of high-sensitivity C-reactive protein and triglyceride glucose index on cardiometabolic multimorbidity.Frontiers in endocrinology · 2025Article
- Association of C-reactive protein to albumin ratio with all-cause and cardiovascular mortality in patients with chronic kidney disease stages 3-5.Environmental health and preventive medicine · 2025Article
- An inverted U-shaped association between high-sensitivity C-reactive protein and the albumin ratio and hepatic steatosis and liver fibrosis: a population-based study.Frontiers in nutrition · 2025Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe high levels of C reactive protein (CRP) to albumin ratio (CAR) is thought to increase the risk of poor outcomes for cancer and cardiovascular disease (CVD). However, the association between CAR and CVD in the Chinese community population has not been investigated.
objectiveThe aim of this study was to investigate the association between CAR and CVD in the Chinese community population.
methodsA total of 62 067 participants without a history of CVD or cancer were included in this study. Kaplan-Meier survival curves were used to calculate the cumulative incidence of endpoint events in CAR quartile groups, and the results were tested by log-rank test. Fine-Gray model was used to analyse the competing risk of death. C-index, Net Reclassification Index (NRI) and Integrated Discrimination Improvement Index (IDI) of different indicators were calculated to distinguish the predictive performance of different indicators.
resultsDuring an average follow-up period of 10.3±2.1 years, 4025 participants developed CVD. In multivariable Cox regression analysis, compared with Q1 group, model 3 showed that the hazard ratio (HR) (95% confidence interval (95%CI)) of CVD in Q4 group was 1.26 (1.15 to 1.38) (p<0.01), and the HR (95% CI) per 1 SD increase was 1.06 (1.03 to 1.08) (p<0.01). The C-index, continuous NRI and IDI for predicting 10-year CVD were 73.48%, 0.1366 (0.1049 to 0.1684) (p<0.01) and 0.0002 (0.0001 to 0.0004) (p<0.01), respectively, which were higher than those of hs-CRP (C-index:0.7344, NRI:0.0711, IDI: 0.0001) and albumin (C-index:0.7339, NRI: -0.0090, IDI: 0.0000).
conclusionHigh levels of CAR can increase the risk of CVD and the predictive performance of CAR for CVD is better than that of hs-CRP or albumin alone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.