Evidence map›Paper›PMID 37563071›Full record

ArticleSleep health2024

Proteomic insights into the pathophysiology of periodic limb movements and restless legs syndrome.

Katie L J Cederberg, Vicente Peris Sempere, Ling Lin, Jing Zhang, Eileen B Leary, Hyatt Moore, Anne M Morse, Adam Blackman, Paula K Schweitzer, Suresh Kotagal and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Katie L J CederbergDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Vicente Peris SempereDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Ling LinDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Jing ZhangDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Eileen B LearyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA; Axsome Therapeutics, New York, NY, USA.
Hyatt MooreDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Anne M MorseDivision of Pediatric Sleep Medicine, Geisinger, Danville, PA, USA; Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
Adam BlackmanDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Paula K SchweitzerSleep Medicine & Research Center, St. Luke's Hospital, Chesterfield, MO, USA.
Suresh KotagalDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Richard BoganDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Clete A KushidaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
STAGES cohort investigator group
Emmanuel MignotDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA. Electronic address: mignot@stanford.edu.
Stanford University · USAxsome Therapeutics (United States) · USGeisinger Medical Center · USMayo Clinic in Arizona · USMedical University of South Carolina · USStanford Medicine · USSt. Luke's Hospital · USUniversity of Toronto · CA

Funding

National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
Multi-Institutional Training in Genetic/Genomic Approaches to Sleep DisordersT32HL110952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHERVIN, RONALD D, MIGNOT, EMMANUEL J · 2013 to 2022
$5.0M
NHLBI NIH HHS R24 HL114473NHLBI NIH HHS T32 HL110952
6 · The paper itself

Abstract

objectivesWe used a high-throughput assay of 5000 plasma proteins to identify biomarkers associated with periodic limb movements (PLM) and restless legs syndrome (RLS) in adults.

methodsParticipants (n = 1410) of the Stanford Technology Analytics and Genomics in Sleep (STAGES) study had blood collected, completed a sleep questionnaire, and underwent overnight polysomnography with the scoring of PLMs. An aptamer-based array (SomaScan) was used to quantify 5000 proteins in plasma. A second cohort (n = 697) that had serum assayed using a previous iteration of SomaScan (1300 proteins) was used for replication and in a combined analysis (n = 2107). A 5% false discovery rate was used to assess significance.

resultsMultivariate analyses in STAGES identified 68 proteins associated with the PLM index after correction for multiple testing (ie, base model). Most significantly decreased proteins were iron-related and included Hepcidin (LEAP-1), Ferritin, and Ferritin light chain. Most significantly increased proteins included RANTES, Cathepsin A, and SULT 1A3. Of 68 proteins significant in the base model, 17 were present in the 1300 panel, and 15 of 17 were replicated. The most significant proteins in the combined model were Hepcidin (LEAP-1), Cathepsin A, Ferritin, and RANTES. Exploration of proteins in RLS versus non-RLS identified Cathepsin Z, Heme oxygenase 2 (HO-2), Interleukin-17A (upregulated in the combined cohort), and Megalin (upregulated in STAGES only) although results were less significant than for proteins associated with PLM index.

conclusionsThese results confirm the association of PLM with low iron status and suggest the involvement of catabolic enzymes in PLM/RLS.

Indexed as

Nocturnal Myoclonus SyndromeRestless Legs SyndromeAdultCathepsin AFerritinsHepcidinsHumansIronProteomicsCathepsin AFerritinsHepcidinsIronBiomarkersMachine learningPeriodic limb movementsProteomicsRestless legs syndrome

Identifiers

PMID37563071
PMCPMC10850434
OpenAlexW4385703238

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.