Evidence map›Paper›PMID 37563155›Full record

ArticleCell death & disease2023

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.

Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero and 26 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Loss ofJHEP reports : innovation in hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 8 institutions in 4 countries.

Kang Zheng *Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.ORCID 0000-0001-6778-2607
Fengjie Hao *Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Sandra Medrano-Garcia *Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Chaobo Chen *Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.ORCID 0000-0001-5963-5295
Feifei GuoDepartment of Obstetrics and Gynaecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Laura Morán-BlancoDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Sandra Rodríguez-PeralesMolecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Raúl Torres-RuizMolecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
María Isabel PeligrosServicio de Anatomía Patológica Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Javier VaqueroServicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rafael BañaresServicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Manuel Gómez Del Moral12 de Octubre Health Research Institute (imas12), Madrid, Spain.
José R RegueiroDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Eduardo Martínez-NavesDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Mohamed Ramadan MohamedDepartment of Clinical Medicine III, University Hospital Aachen, UKA, Aachen, Germany.ORCID 0000-0002-2101-2030
Rocío Gallego-DuránInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Douglas MayaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Javier AmpueroInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Manuel Romero-GómezInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Albert Gilbert-RamosInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Sergi Guixé-MuntetInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Anabel Fernández-IglesiasInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Jordi Gracia-SanchoInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Mar CollInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Isabel GrauperaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Pere GinèsInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Andreea CiudinEndocrinology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute for Research (VHIR), Barcelona, Spain.
Jesús Rivera-EstebanLiver Unit, Internal Medicine Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute for Research (VHIR), Barcelona, Spain.
Juan M PericàsInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
María Dolores FrutosDepartment of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
Bruno Ramos MolinaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
José María HerranzInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Matías A ÁvilaInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Yulia A NevzorovaDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Edgar Fernández-MalavéDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain.
Francisco Javier CuberoDepartment of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, Madrid, Spain. fcubero@ucm.es.ORCID 0000-0003-1499-650X
Hospital General Universitario Gregorio Marañón · ESUniversidad Complutense de Madrid · ESSpanish National Cancer Research Centre · ESUniversity of Bern · CHVall d'Hebron Institut de Recerca · ESHospital Universitario Virgen de la Arrixaca · ESNanjing Drum Tower Hospital · CNUniversitätsklinikum Aachen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-binding proteins also encompassing the highly homologous H-RAS and K-RAS isoforms, was previously reported to modulate cell death and renal fibrosis; however, its role in liver damage and fibrogenesis remains unknown. Here, we approached this question by using N-RAS deficient (N-RAS

Indexed as

Liver CirrhosisNeuroblastomaAnimalsCarbon TetrachlorideHepatic Stellate CellsHumansLiverMiceMonomeric GTP-Binding ProteinsOncogenesCarbon TetrachlorideMonomeric GTP-Binding ProteinsNras protein, mouse

Identifiers

PMID37563155
PMCPMC10415403
OpenAlexW4385724381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.