ArticleNature medicine2023
Factors associated with healthy aging in Latin American populations.
Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
98 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A Systematic Review of Available Normative Data on Neuropsychological Tests for Spanish Speakers in the U.S., Latin America and the Caribbean, and Spain.Neuropsychology review · 2026Pooled it
- Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women.Frontiers in aging neuroscience · 2026Pooled it
- Healthy aging meta-analyses and scoping review of risk factors across Latin America reveal large heterogeneity and weak predictive models.Nature aging · 2024Pooled it
- Health inequalities in a middle-income country: a systematic review of the Costa Rican case.Frontiers in public health · 2024Pooled it
- Speech clocks decode dementia phenotypes, social exposome, and biological aging.Science advances · 2026Article
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations between socioeconomic status and adverse childhood experiences with multidimensional healthy aging: findings from ELSI-Brazil.BMC public health · 2026Article
- Benchmarking speech biomarkers of Alzheimer's against cognitive and neural measures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Health status characteristics and aging determinants of centenarians in Colombia: a real-life expanded cohort profile description.BMC geriatrics · 2026Article
- Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort.Alzheimer's research & therapy · 2026Article
- Prevalence of dementia and mild cognitive impairment in the Mexican population: evidence from Mex-Cog, a harmonized cognitive assessment protocol study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Social disadvantage outweighs knowledge in dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- Towards a Latin American neuropsychiatry: challenges and opportunities.Lancet regional health. Americas · 2026Review
- Accounting for inequality in dementia prevention programmes.Bulletin of the World Health Organization · 2026Article
38 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
Abstract
Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.