Evidence map›Paper›PMID 37565064›Full record

Observational studyFrontiers in cellular and infection microbiology2023

Establishment of a mathematical prediction model for voriconazole stable maintenance dose: a prospective study.

Lijuan Zhou, Min Li, Huihong Li, Zhiqiang Guo, Yanqiu Gao, Hua Zhang, Fuli Qin, Zhihui Sang, Qinghe Xing, Long Cheng and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lijuan ZhouTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Min LiTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Huihong LiTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Zhiqiang GuoDepartment of Hematology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Yanqiu GaoDepartment of Respiratory Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Hua ZhangDepartment of Respiratory Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Fuli QinDepartment of Hematology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Zhihui SangTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Qinghe XingInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Long ChengCollege of Nursing, Chifeng University, Chifeng, Inner Mongolia, China.
Wei CaoTranslational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Zhengzhou Central Hospital · CNChifeng University · CNChildren's Hospital of Fudan University · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In patients with invasive fungal infection (IFI), the steady-state serum trough concentration ( Aims: This randomized, prospective observational single-center study aimed to identify factors affecting VCZ- Results: Results indicated that CYP2C19 genetic polymorphisms might significantly impact VCZ loading and maintenance dose selection. CYP2C19 phenotype, C-reaction protein (CRP), and average daily dose/body weight were significant influencers on VCZ- Discussion: DiThis formula may serve as a valuable supplement to the Clinical Pharmacogenetics Implementation Consortium (CPIC

Indexed as

Antifungal AgentsInvasive Fungal InfectionsC-Reactive ProteinCytochrome P-450 CYP2C19HumansProspective StudiesVoriconazoleAntifungal AgentsC-Reactive ProteinCytochrome P-450 CYP2C19VoriconazoleCYP2C19prediction modelproinflammatory cytokinessecurityvoriconazole

Identifiers

PMID37565064
PMCPMC10410275
OpenAlexW4385318367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.