Evidence map›Paper›PMID 37566199›Full record

ArticleMolecular diversity2024

A green one-pot synthetic protocol of hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one derivatives: molecular docking, ADMET, anticancer and antimicrobial studies.

Harsh D Trivedi, Bonny Y Patel, Sanjay D Hadiyal, Gopal Italiya, Prasanna Srinivasan Ramalingam

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Harsh D TrivediDepartment of Chemistry, B.V. Shah (Vadi-Vihar) Science College, C.U. Shah University, Wadhwan City, Gujarat, 363001, India.
Bonny Y PatelDepartment of Chemistry, School of Science, RK University, Rajkot, Gujarat, 360020, India. bonny.y.patel@gmail.com.ORCID http://orcid.org/0000-0002-7017-7026
Sanjay D HadiyalDepartment of Chemistry, Atmiya University, Rajkot, Gujarat, 360005, India.
Gopal ItaliyaSchool of Bio Science and Technology (SBST), Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Prasanna Srinivasan RamalingamSchool of Bio Science and Technology (SBST), Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Funding

Department of Education, Gujarat Government, India 202001260001
6 · The paper itself

Abstract

Ten hexahydropyrimido[4,5-d]pyrimidine derivatives have been synthesized by using a green and time-efficient microwave method. The synthesized motifs were evaluated for their anticancer activity, antimicrobial activity, molecular docking, drug likeliness and ADMET studies. Comparatively, the hetero-aromatic pyrazole substituted compound 4a exhibited the highest anticancer activity [Mean growth percent: 35.57], while EDG [-N(CH

Indexed as

Anti-Infective AgentsAntineoplastic AgentsMolecular Docking SimulationMolecular StructureNitrogen DioxidePyrimidinesStructure-Activity RelationshipAnti-Infective AgentsAntineoplastic AgentsNitrogen DioxidePyrimidinesADMETAnticancerAntimicrobialGreen synthesisMolecular dockingPyrimido[4,5-d]pyrimidine

Identifiers

PMID37566199

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.