Evidence map›Paper›PMID 37568364›Full record

ArticleJournal of clinical medicine2023

Virtual Reality Technology to Enhance Conventional Rehabilitation Program: Results of a Single-Blind, Randomized, Controlled Pilot Study in Patients with Global Developmental Delay.

Carmela Settimo, Maria Cristina De Cola, Erica Pironti, Rosalia Muratore, Fabio Mauro Giambò, Angelo Alito, Maria Tresoldi, Margherita La Fauci, Carmela De Domenico, Emanuela Tripodi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Carmela SettimoIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.ORCID 0000-0001-9643-349X
Maria Cristina De ColaIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.ORCID 0000-0002-7509-3833
Erica PirontiWoman-Child Department, Unit of Child Neurology and Psychiatry, Policlinico Riuniti Foggia, 71122 Foggia, Italy.
Rosalia MuratoreIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Fabio Mauro GiambòIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Angelo AlitoDepartment of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-6609-579X
Maria TresoldiIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Margherita La FauciIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Carmela De DomenicoIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Emanuela TripodiIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Caterina ImpallomeniIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Francesca CucinottaIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.ORCID 0000-0001-8477-7826
Centro Neurolesi Bonino Pulejo · ITOspedali Riuniti di Foggia · ITUniversity of Messina · IT

Funding

Ministry of Health, Italy Current Research Funds 2023
6 · The paper itself

Abstract

Global developmental delay (GDD) is a complex disorder that requires multimodal treatment involving different developmental skills. The objective of this single-blind, randomized, controlled pilot study is to evaluate the feasibility and effectiveness of conventional rehabilitation programs integrated with the BTs-Nirvana virtual reality system. Patients with GDD aged 12 to 66 months were enrolled and treated for a 48-session cycle. Patients were randomized into two groups, (1) conventional treatment and (2) conventional treatment supplemented with the use of BTs-Nirvana, in a 1:1 ratio. Before and after treatments, areas of global development were tested with the Griffiths-III Mental Developmental Scale and the clinical indicator of global improvement were measured with the Clinical Global Impressions-Improvement (CGI-I). Feasibility was confirmed by the high retention rate. The experimental group presented a significantly improvement in General Quotient (GQ) after treatment (GQ,

Indexed as

childearly interventioneducationalneurodevelopmental disorderspreschoolrandomized controlled trialvirtual reality exposure therapy

Identifiers

PMID37568364
PMCPMC10419390
OpenAlexW4385346111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.