Evidence map›Paper›PMID 37568827›Full record

ArticleCancers2023

YY1 Knockdown Relieves the Differentiation Block and Restores Apoptosis in AML Cells.

Nelida Ines Noguera, Serena Travaglini, Stefania Scalea, Caterina Catalanotto, Anna Reale, Michele Zampieri, Alessandra Zaza, Maria Rosaria Ricciardi, Daniela Francesca Angelini, Agostino Tafuri and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Nelida Ines NogueraDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0001-7682-862X
Serena TravagliniDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-5411-1502
Stefania ScaleaDepartment of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
Caterina CatalanottoDepartment of Molecular Medicine, Sapienza University, 00185 Rome, Italy.
Anna RealeDepartment of Molecular Medicine, Sapienza University, 00185 Rome, Italy.
Michele ZampieriDepartment of Molecular Medicine, Sapienza University, 00185 Rome, Italy.
Alessandra ZazaUnit of Neuro-Oncoematologia, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.
Maria Rosaria RicciardiDepartment of Clinical and Molecular Medicine, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-8772-3521
Daniela Francesca AngeliniLaboratory of Neuro-Immunology and Cytofluorimetry, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.ORCID 0000-0003-4552-9226
Agostino TafuriDepartment of Clinical and Molecular Medicine, Sapienza University, 00185 Rome, Italy.
Tiziana OttoneDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.
Maria Teresa VosoDepartment of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-6164-4761
Giuseppe ZardoDepartment of Experimental Medicine, Sapienza University, 00185 Rome, Italy.
Sapienza University of Rome · ITUniversity of Rome Tor Vergata · ITFondazione Santa Lucia · IT

Funding

Italian Association for Cancer Research MYNERVA project, #21267Sapienza University of Rome C26A15S3JR
6 · The paper itself

Abstract

In this study we analyzed the expression of Yin and Yang 1 protein (YY1), a member of the noncanonical PcG complexes, in AML patient samples and AML cell lines and the effect of YY1 downregulation on the AML differentiation block. Our results show that YY1 is significantly overexpressed in AML patient samples and AML cell lines and that YY1 knockdown relieves the differentiation block. YY1 downregulation in two AML cell lines (HL-60 and OCI-AML3) and one AML patient sample restored the expression of members of the CEBP protein family, increased the expression of extrinsic growth factors/receptors and surface antigenic markers, induced morphological cell characteristics typical of myeloid differentiation, and sensitized cells to retinoic acid treatment and to apoptosis. Overall, our data show that YY1 is not a secondary regulator of myeloid differentiation but that, if overexpressed, it can play a predominant role in myeloid differentiation block.

Indexed as

acute myeloid leukemiaall-trans retinoic acidC/EBPsPolycomb proteinsRARαYY1

Identifiers

PMID37568827
PMCPMC10417667
OpenAlexW4385654885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.