Evidence map›Paper›PMID 37569290›Full record

ArticleInternational journal of molecular sciences2023

Magnetic Nanoemulsions for the Intra-Articular Delivery of Ascorbic Acid and Dexamethasone.

Camelia Mihaela Zară-Dănceanu, Cristina Stavilă, Anca Emanuela Minuti, Luminiţa Lăbușcă, Valentin Nastasa, Dumitru-Daniel Herea, Răzvan-Nicolae Malancus, Daniel Ghercă, Sorin-Aurelian Pasca, Horia Chiriac and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Camelia Mihaela Zară-DănceanuDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.ORCID 0000-0002-3400-2421
Cristina StavilăDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.ORCID 0009-0002-5719-710X
Anca Emanuela MinutiDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.
Luminiţa LăbușcăDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.ORCID 0000-0001-9635-6893
Valentin NastasaFaculty of Veterinary Medicine, "Ion Ionescu de la Brad" University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iaşi, Romania.ORCID 0000-0001-7384-8692
Dumitru-Daniel HereaDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.ORCID 0000-0002-8455-8380
Răzvan-Nicolae MalancusFaculty of Veterinary Medicine, "Ion Ionescu de la Brad" University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iaşi, Romania.ORCID 0000-0001-9139-4700
Daniel GhercăDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.
Sorin-Aurelian PascaFaculty of Veterinary Medicine, "Ion Ionescu de la Brad" University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iaşi, Romania.ORCID 0000-0002-9519-8122
Horia ChiriacDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.
Mihai MaresFaculty of Veterinary Medicine, "Ion Ionescu de la Brad" University of Life Sciences (IULS), 8 Mihail Sadoveanu Alley, 700489 Iaşi, Romania.ORCID 0000-0002-3103-4954
Nicoleta LupuDepartment of Magnetic Materials and Devices, National Institute of Research and Development for Technical Physics, 700050 Iaşi, Romania.ORCID 0000-0003-2188-8187
National Institute of Research and Development for Technical Physics · RO"Ion Ionescu de la Brad" Iasi University of Life Sciences · ROAlexandru Ioan Cuza University · ROSpitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi · RO

Funding

Ministry of Research, Innovation and Digitization CNCS-UEFISCDI PN-III-P4-PCE-2021-1081 within PNCDI III (Contract no. 75/2022)number ERANET-EURONANOMED-3-OASIs, within PNCDI III (contract number 273/2022) number ERANET-EURONANOMED-3-OASIs, within PNCDI III (contract number 273/2022)
6 · The paper itself

Abstract

(1) Osteoarthritis (OA) is a progressive joint degenerative disease that currently has no cure. Limitations in the development of innovative disease modifying therapies are related to the complexity of the underlying pathogenic mechanisms. In addition, there is the unmet need for efficient drug delivery methods. Magnetic nanoparticles (MNPs) have been proposed as an efficient modality for the delivery of bioactive molecules within OA joints, limiting the side effects associated with systemic delivery. We previously demonstrated MNP's role in increasing cell proliferation and chondrogenesis. In the design of intra-articular therapies for OA, the combined NE-MNP delivery system could provide increased stability and biological effect. (2) Proprietary Fe

Indexed as

Cartilage, ArticularOsteoarthritisAnimalsAscorbic AcidCartilageChondrogenesisDexamethasoneHumansMagnetic PhenomenaMiceAscorbic AcidDexamethasoneadipose derived mesenchymal cellsbiocompatibilitychondrogenesismagnetic nanoemulsionmagnetic nanoparticlesnanoemulsionwound healing

Identifiers

PMID37569290
PMCPMC10419142
OpenAlexW4385318523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.